Thiazole ring—A biologically active scaffold
A Petrou, M Fesatidou, A Geronikaki - Molecules, 2021 - mdpi.com
Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …
applications. Its derivatives have a wide range of biological activities such as antioxidant …
Thiazole-containing compounds as therapeutic targets for cancer therapy
In the last few decades, considerable progress has been made in anticancer agents
development, and several new anticancer agents of natural and synthetic origin have been …
development, and several new anticancer agents of natural and synthetic origin have been …
Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids
A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …
molecule are basically designed to interact with multiple targets or to amplify its effect …
Solvent-free heterocyclic synthesis
MAP Martins, CP Frizzo, DN Moreira, L Buriol… - Chemical …, 2009 - ACS Publications
Heterocycles form, by far, the largest of the classical divisions of organic chemistry.
Moreover, they are of immense importance not only biologically and industrially but also to …
Moreover, they are of immense importance not only biologically and industrially but also to …
Synthesis, anticancer activity and molecular modeling studies of 1, 2, 4-triazole derivatives as EGFR inhibitors
A series of novel compounds carrying 1, 2, 4-triazole scaffold were prepared and evaluated
for their antiproliferative activities against NCI 60 cell line. Compounds 10 (a, c), 11 (ad), and …
for their antiproliferative activities against NCI 60 cell line. Compounds 10 (a, c), 11 (ad), and …
Synthesis and biological evaluation of simple methoxylated chalcones as anticancer, anti-inflammatory and antioxidant agents
BP Bandgar, SS Gawande, RG Bodade… - Bioorganic & medicinal …, 2010 - Elsevier
Chalcones have been identified as interesting compounds with cytotoxicity, anti-
inflammatory and antioxidant properties. In the present study, simple methoxychalcones …
inflammatory and antioxidant properties. In the present study, simple methoxychalcones …
Synthesis and in vitro antitumor activity of substituted quinazoline and quinoxaline derivatives: search for anticancer agent
The synthesis of some 2-furano-4 (3H)-quinazolinones, diamides (open ring quinazolines),
quinoxalines and their biological evaluation as antitumor agents using National Cancer …
quinoxalines and their biological evaluation as antitumor agents using National Cancer …
Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline–thiazolidine-based hybrids
The features of the chemistry of 4-thiazolidinone and pyrazole/pyrazolines as
pharmacologically attractive scaffolds were described in a number of reviews in which the …
pharmacologically attractive scaffolds were described in a number of reviews in which the …
Medicinal importance, coordination chemistry with selected metals (Cu, Ag, Au) and chemosensing of thiourea derivatives. A review
Thiourea and its derivatives are versatile compounds used in several fields of life ranging
from medicinal to chemosensor applications. In this review article, generally used …
from medicinal to chemosensor applications. In this review article, generally used …
Recent development of sulfonyl or sulfonamide hybrids as potential anticancer agents: A key review
KP Rakesh, SM Wang, J Leng… - Anti-Cancer Agents …, 2018 - ingentaconnect.com
Cancer is the second leading cause of death worldwide. There is always a huge demand for
novel anticancer drugs and diverse new natural or synthetic compounds are developed …
novel anticancer drugs and diverse new natural or synthetic compounds are developed …