Alzheimer disease (AD) is the most common type of dementia, and is currently incurable;
existing treatments for AD produce only a modest amelioration of symptoms. Research into …

It has been hypothesized that alterations in the composition of the gut microbiota might be
associated with the onset of certain human pathologies, such as Alzheimer disease, a …

Multifactorial mechanisms underlying late-onset Alzheimer's disease (LOAD) are poorly
characterized from an integrative perspective. Here spatiotemporal alterations in brain …

Cerebral amyloid-β (Aβ) accumulation due to impaired Aβ clearance is a pivotal event in the
pathogenesis of Alzheimer's disease (AD). Considerable brain-derived Aβ is cleared via …

The pathological processes leading to synapse loss, neuronal loss, brain atrophy and
gliosis in Alzheimer's disease (AD) and their relation to vascular disease and immunological …

This review considers efflux of substances from brain parenchyma quantified as values of
clearances (CL, stated in µL g− 1 min− 1). Total clearance of a substance is the sum of …

According to the neurovascular hypothesis, impairment of low-density lipoprotein receptor–
related protein-1 (LRP1) in brain capillaries of the blood-brain barrier (BBB) contributes to …

The blood–brain barrier (BBB) is an evolutionarily conserved, structural, and functional
separation between circulating blood and the central nervous system (CNS). By controlling …

Alzheimer's disease (AD) is the most common type of dementia, and no disease-modifying
treatments are available to halt or slow its progression. Amyloid-beta (Aβ) is suggested to …

ABC (ATP-binding cassette) transporters represent one of the largest and most diverse
superfamily of proteins in living species, playing an important role in many biological …