The ability of the brain to store and process information relies on changing the strength of
connections between neurons. Synaptic facilitation is a form of short-term plasticity that …

Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …

Although astrocytes constitute nearly half of the cells in our brain, their function is a long-
standing neurobiological mystery. Here we show by quantal analyses, FM1-43 imaging …

The intracellular calcium concentration ([Ca 2+]) has important roles in the triggering of
neurotransmitter release and the regulation of short-term plasticity (STP). Transmitter …

Neurotransmitter release at synapses between nerve cells is mediated by calcium-triggered
exocytotic fusion of synaptic vesicles. Before fusion, vesicles dock at the presynaptic release …

Synapse,” intended to contrast our grasp of presynaptic Angleson and Betz (1997) quite
recently reviewed in physiology with our understanding of postsynaptic detail techniques for …

Synaptic vesicles must be primed to fusion competence before they can fuse with the
plasma membrane in response to increased intracellular Ca2+ levels. The presynaptic …

In neocortical circuits, repetitively active neurons evoke unitary postsynaptic potentials
(PSPs) whose peak amplitudes either increase (facilitate) or decrease (depress) …

Regulated exocytosis of secretory granules or dense-core granules has been examined in
many well-characterized cell types including neurons, neuroendocrine, endocrine, exocrine …

The size of a pool of readily releasable vesicles at a giant brainstem synapse, the calyx of
Held, was probed with three independent approaches. Using simultaneous pre-and …