The discoveries leading to our present understanding of the glutathione peroxidases (GPxs)
are recalled. The cytosolic GPx, now GPx1, was first described by Mills in 1957 and claimed …

Selenium is an essential micronutrient with important functions in human health and
relevance to several pathophysiological conditions. The biological effects of selenium are …

Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all
cells by mitochondrial and enzymatic sources. Left unchecked, these reactive species can …

Publisher Summary To determine glutathione peroxidase reliably, some factors of potential
pitfall have to be considered, for example, enzymatic side reactions of substrates (especially …

Glutathione peroxidase activity in the liver supernatant from rats fed a Se-deficient diet for 2
weeks was 8% of control when measured with H 2 O 2 but 42% of control when assayed …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Arsenic occurs naturally in the earth's crust and is widely distributed in the environment.
Natural mineralization and activities of microorganisms enhance arsenic mobilization in the …

The endogenous defenses of the mouse heart against reactive oxygen metabolites were
investigated. The activities of three enzymes capable of detoxifying activated oxygen were …

One of the requirements for fife is the maintenance of molecules in a reduced state even
though they are exposed to an oxidizing atmosphere. Another requirement is the generation …

Publisher Summary Gluthatione peroxidase is assayed by a modification of the method of
Paglia and Valentine. Glutathione peroxidase catalyzes the reduction of hydroperoxides …