Neuromodulation of neuronal circuits: back to the future
E Marder - Neuron, 2012 - cell.com
All nervous systems are subject to neuromodulation. Neuromodulators can be delivered as
local hormones, as cotransmitters in projection neurons, and through the general circulation …
local hormones, as cotransmitters in projection neurons, and through the general circulation …
Ion channel degeneracy, variability, and covariation in neuron and circuit resilience
JM Goaillard, E Marder - Annual review of neuroscience, 2021 - annualreviews.org
The large number of ion channels found in all nervous systems poses fundamental
questions concerning how the characteristic intrinsic properties of single neurons are …
questions concerning how the characteristic intrinsic properties of single neurons are …
Cell types, network homeostasis, and pathological compensation from a biologically plausible ion channel expression model
How do neurons develop, control, and maintain their electrical signaling properties in spite
of ongoing protein turnover and perturbations to activity? From generic assumptions about …
of ongoing protein turnover and perturbations to activity? From generic assumptions about …
Variability, compensation, and modulation in neurons and circuits
E Marder - Proceedings of the National Academy of …, 2011 - National Acad Sciences
I summarize recent computational and experimental work that addresses the inherent
variability in the synaptic and intrinsic conductances in normal healthy brains and shows that …
variability in the synaptic and intrinsic conductances in normal healthy brains and shows that …
Neuromodulation of circuits with variable parameters: single neurons and small circuits reveal principles of state-dependent and robust neuromodulation
Neuromodulation underlies many behavioral states and has been extensively studied in
small circuits. This has allowed the systematic exploration of how neuromodulatory …
small circuits. This has allowed the systematic exploration of how neuromodulatory …
[HTML][HTML] Exome sequencing of ion channel genes reveals complex profiles confounding personal risk assessment in epilepsy
Ion channel mutations are an important cause of rare Mendelian disorders affecting brain,
heart, and other tissues. We performed parallel exome sequencing of 237 channel genes in …
heart, and other tissues. We performed parallel exome sequencing of 237 channel genes in …
A biophysical perspective on the resilience of neuronal excitability across timescales
Neuronal membrane excitability must be resilient to perturbations that can take place over
timescales from milliseconds to months (or even years in long-lived animals). A great deal of …
timescales from milliseconds to months (or even years in long-lived animals). A great deal of …
Correlations in ion channel expression emerge from homeostatic tuning rules
Experimental observations reveal that the expression levels of different ion channels vary
across neurons of a defined type, even when these neurons exhibit stereotyped electrical …
across neurons of a defined type, even when these neurons exhibit stereotyped electrical …
Robust circuit rhythms in small circuits arise from variable circuit components and mechanisms
Highlights•Analysis of small oscillatory circuits reveals variability in system
parameters.•Circuits with different parameter sets can be robust to moderate …
parameters.•Circuits with different parameter sets can be robust to moderate …
Visualization of currents in neural models with similar behavior and different conductance densities
Conductance-based models of neural activity produce large amounts of data that can be
hard to visualize and interpret. We introduce visualization methods to display the dynamics …
hard to visualize and interpret. We introduce visualization methods to display the dynamics …