Osteoarthritis (OA) affects more than 500 million people worldwide and is among the five
diseases in Germany causing the highest suffering of the patients and cost for the society …

Bone infections are characterized by bacterial invasion of the bone microenvironment and
subsequent bone structure deterioration. This holds significance because osteoclasts, which …

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of
osteoporosis, which is characterized by increased bone resorption and inadequate bone …

The complement fragment C5a is a core effector of complement activation. C5a, acting
through its major receptor C5aR1, exerts powerful pro-inflammatory and immunomodulatory …

Irradiation‑induced bone remodeling imbalances arise as a consequence of the
dysregulation of bone formation and resorption. Due to the abundance of osteocytes, their …

Bone remodeling is a physiological, dynamic process that mainly depends on the functions
of 2 cell types: osteoblasts and osteoclasts. Emerging evidence suggests that complement …

The complement activation peptide C5a is a key mediator of inflammation that is associated
with numerous immune disorders. C5a binds and activates two seven-transmembrane …

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of
osteoporosis, which is characterized by increased bone resorption and inadequate bone …

The complement system is an important part of the innate immune system, which is activated
by endogenous or exogenous pathogens. The main functions of the complement system are …

Effekte eines Osteoklasten-spezifischen C5aR1 Knockouts auf den Knochenphänotyp der
Maus Page 1 Universität Ulm Institut für Unfallchirurgische Forschung und Biomechanik …