Advances in single-cell RNA sequencing and its applications in cancer research
D Huang, N Ma, X Li, Y Gou, Y Duan, B Liu… - Journal of hematology & …, 2023 - Springer
Cancers are a group of heterogeneous diseases characterized by the acquisition of
functional capabilities during the transition from a normal to a neoplastic state. Powerful …
functional capabilities during the transition from a normal to a neoplastic state. Powerful …
Enhancing head and neck tumor management with artificial intelligence: Integration and perspectives
NN Zhong, HQ Wang, XY Huang, ZZ Li, LM Cao… - Seminars in Cancer …, 2023 - Elsevier
Head and neck tumors (HNTs) constitute a multifaceted ensemble of pathologies that
primarily involve regions such as the oral cavity, pharynx, and nasal cavity. The intricate …
primarily involve regions such as the oral cavity, pharynx, and nasal cavity. The intricate …
A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors
Single-cell genomics is essential to chart tumor ecosystems. Although single-cell RNA-Seq
(scRNA-Seq) profiles RNA from cells dissociated from fresh tumors, single-nucleus RNA …
(scRNA-Seq) profiles RNA from cells dissociated from fresh tumors, single-nucleus RNA …
Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma
Head and neck squamous cell carcinoma (HNSCC) includes a subset of cancers driven by
human papillomavirus (HPV). Here we use single-cell RNA-seq to profile both HPV-positive …
human papillomavirus (HPV). Here we use single-cell RNA-seq to profile both HPV-positive …
Partial EMT in head and neck cancer biology: a spectrum instead of a switch
Our understanding of epithelial-to-mesenchymal transition (EMT) has slowly evolved from a
simple two state, binary model to a multi-step, dynamic continuum of epithelial-to …
simple two state, binary model to a multi-step, dynamic continuum of epithelial-to …
Microenvironment-driven intratumoral heterogeneity in head and neck cancers: clinical challenges and opportunities for precision medicine
H Zaryouh, M Vara-Messler, J Vignau… - Drug Resistance …, 2022 - Elsevier
Squamous cell carcinoma of the head and neck (SCCHN) is among the most prevalent
cancer types worldwide. Despite multimodal therapeutic approaches that include surgical …
cancer types worldwide. Despite multimodal therapeutic approaches that include surgical …
Single-cell transcriptome and antigen-immunoglobin analysis reveals the diversity of B cells in non-small cell lung cancer
Background Malignant transformation and progression of cancer are driven by the co-
evolution of cancer cells and their dysregulated tumor microenvironment (TME). Recent …
evolution of cancer cells and their dysregulated tumor microenvironment (TME). Recent …
Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response
The spatial organization of the tumor microenvironment has a profound impact on biology
and therapy response. Here, we perform an integrative single-cell and spatial transcriptomic …
and therapy response. Here, we perform an integrative single-cell and spatial transcriptomic …
ACE2 and furin expressions in oral epithelial cells possibly facilitate COVID-19 infection via respiratory and fecal–oral routes
Background: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) that mainly transfers from human to human via …
syndrome coronavirus 2 (SARS-CoV-2) that mainly transfers from human to human via …
New insights into oral squamous cell carcinoma: From clinical aspects to molecular tumorigenesis
SH Chen, SY Hsiao, KY Chang, JY Chang - International journal of …, 2021 - mdpi.com
Oral squamous cell carcinoma (SCC) is a prevalent malignant disease worldwide,
especially so in Taiwan. Early-or even preclinical-stage detection is critical for reducing …
especially so in Taiwan. Early-or even preclinical-stage detection is critical for reducing …