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Pathway of human AS3MT arsenic methylation
A synthetic gene encoding human As (III) S-adenosylmethionine (SAM) methyltransferase
(hAS3MT) was expressed, and the purified enzyme was characterized. The synthetic …
(hAS3MT) was expressed, and the purified enzyme was characterized. The synthetic …
Identification and structural characterization of novel cyclotide with activity against an insect pest of sugar cane
Cyclotides are a family of plant-derived cyclic peptides comprising six conserved cysteine
residues connected by three intermolecular disulfide bonds that form a knotted structure …
residues connected by three intermolecular disulfide bonds that form a knotted structure …
Arsenic methylation by a novel ArsM As(III) S‐adenosylmethionine methyltransferase that requires only two conserved cysteine residues
K Huang, Y Xu, C Packianathan, F Gao… - Molecular …, 2018 - Wiley Online Library
Arsenic (As) biomethylation is an important component of the As biogeochemical cycle that
can influence As toxicity and mobility in the environment. Biomethylation of As is catalyzed …
can influence As toxicity and mobility in the environment. Biomethylation of As is catalyzed …
PDE4 inhibitor eliminates breast cancer stem cells via noncanonical activation of mTOR
Ineffective cancer treatment is implicated in metastasis, recurrence, resistance to
chemotherapy and radiotherapy, and evasion of immune surveillance. All these failures …
chemotherapy and radiotherapy, and evasion of immune surveillance. All these failures …
Quorum quenching activity of pentacyclic triterpenoids leads to inhibition of biofilm formation by Acinetobacter baumannii
The quorum quenching (QQ) potential of three pentacyclic triterpenoids, glycyrrhetinic acid
(GRA), ursolic acid (UA) and betulinic acid (BA), representing distinct groups of compounds …
(GRA), ursolic acid (UA) and betulinic acid (BA), representing distinct groups of compounds …
A disulfide-bond cascade mechanism for arsenic (III) S-adenosylmethionine methyltransferase
Methylation of the toxic metalloid arsenic is widespread in nature. Members of every
kingdom have arsenic (III) S-adenosylmethionine (SAM) methyltransferase enzymes, which …
kingdom have arsenic (III) S-adenosylmethionine (SAM) methyltransferase enzymes, which …
The Structure of an As(III) S-Adenosylmethionine Methyltransferase with 3-Coordinately Bound As(III) Depicts the First Step in Catalysis
Arsenic is a ubiquitous environmental toxic substance and a Class 1 human carcinogen.
Arsenic methylation by the enzyme As (III) S-adenosylmethionine (SAM) methyltransferase …
Arsenic methylation by the enzyme As (III) S-adenosylmethionine (SAM) methyltransferase …
Functional characterization of the methylarsenite‐inducible arsRM operon from Noviherbaspirillum denitrificans HC18
J Zhang, J Chen, YF Wu, X Liu… - Environmental …, 2022 - Wiley Online Library
Microbial arsenic methylation by arsenite (As (III)) S‐adenosylmethionine
methyltransferases (ArsMs) can produce the intermediate methylarsenite (MAs (III)), which is …
methyltransferases (ArsMs) can produce the intermediate methylarsenite (MAs (III)), which is …
Genomewide Analysis of Mode of Action of the S-Adenosylmethionine Analogue Sinefungin in Leishmania infantum
To further our understanding of one-carbon metabolism in the protozoan parasite
Leishmania, we conducted genomic screens to study how the parasite responded to …
Leishmania, we conducted genomic screens to study how the parasite responded to …
Clustering protein environments for function prediction: finding PROSITE motifs in 3D
Background Structural genomics initiatives are producing increasing numbers of three-
dimensional (3D) structures for which there is little functional information. Structure-based …
dimensional (3D) structures for which there is little functional information. Structure-based …