Sand flies: Basic information on the vectors of leishmaniasis and their interactions with Leishmania parasites

P Cecílio, A Cordeiro-da-Silva, F Oliveira - Communications biology, 2022 - nature.com
Blood-sucking arthropods transmit a variety of human pathogens acting as disseminators of
the so-called vector-borne diseases. Leishmaniasis is a spectrum of diseases caused by …

Leishmania development in sand flies: parasite-vector interactions overview

A Dostálová, P Volf - Parasites & vectors, 2012 - Springer
Leishmaniases are vector-borne parasitic diseases with 0.9–1.4 million new human cases
each year worldwide. In the vectorial part of the life-cycle, Leishmania development is …

The Gut Microbiome of the Vector Lutzomyia longipalpis Is Essential for Survival of Leishmania infantum

PH Kelly, SM Bahr, TD Serafim, NJ Ajami, JF Petrosino… - MBio, 2017 - journals.asm.org
The vector-borne disease leishmaniasis, caused by Leishmania species protozoa, is
transmitted to humans by phlebotomine sand flies. Development of Leishmania to infective …

Leishmania, microbiota and sand fly immunity

EL Telleria, A Martins-da-Silva, AJ Tempone… - Parasitology, 2018 - cambridge.org
In this review, we explore the state-of-the-art of sand fly relationships with microbiota, viruses
and Leishmania, with particular emphasis on the vector immune responses. Insect-borne …

Interactions between Leishmania parasite and sandfly: a review

A Tom, NP Kumar, A Kumar, P Saini - Parasitology Research, 2024 - Springer
Leishmaniasis transmission cycles are maintained and sustained in nature by the complex
crosstalk of the Leishmania parasite, sandfly vector, and the mammalian hosts (human, as …

The Role of Leishmania Proteophosphoglycans in Sand Fly Transmission and Infection of the Mammalian Host

ME Rogers - Frontiers in microbiology, 2012 - frontiersin.org
Leishmania are transmitted by the bite of their sand fly vector and this has a significant
influence on the virulence of the resulting infection. From our studies into the interaction …

Colonisation resistance in the sand fly gut: Leishmania protects Lutzomyia longipalpis from bacterial infection

MRV Sant'Anna, H Diaz-Albiter, K Aguiar-Martins… - Parasites & vectors, 2014 - Springer
Background Phlebotomine sand flies transmit the haemoflagellate Leishmania, the
causative agent of human leishmaniasis. The Leishmania promastigotes are confined to the …

Dietary and phylogenetic correlates of digestive trypsin activity in insect pests

J Lazarević, M Janković‐Tomanić - … Experimentalis et Applicata, 2015 - Wiley Online Library
Because food proteins are crucial for insect survival, growth, and fecundity, enzymes
involved in their digestion have attracted the attention of fundamental entomologists …

RNAi-mediated gene silencing of Phlebotomus papatasi defensins favors Leishmania major infection

B Vomáčková Kykalová, F Sassù, P Volf… - Frontiers in …, 2023 - frontiersin.org
Introduction: Production of different antimicrobial peptides (AMPs) is one of the insect's
prominent defense strategies, regulated mainly by Toll and immune deficiency (IMD) …

Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies

N Secundino, N Kimblin, NC Peters… - Cellular …, 2010 - Wiley Online Library
Leishmania synthesize abundant phosphoglycan‐containing molecules made up of [Gal‐
Man‐PO4] repeating units, including the surface lipophosphoglycan (LPG), and the surface …