The pentose phosphate pathway in health and disease

T TeSlaa, M Ralser, J Fan, JD Rabinowitz - Nature metabolism, 2023 - nature.com
The pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …

Metabolic reprogramming in cancer: Mechanisms and therapeutics

S Nong, X Han, Y **ang, Y Qian, Y Wei, T Zhang… - MedComm, 2023 - Wiley Online Library
Cancer cells characterized by uncontrolled growth and proliferation require altered
metabolic processes to maintain this characteristic. Metabolic reprogramming is a process …

[HTML][HTML] Impact of microplastic residues from polyurethane films on crop growth: Unraveling insights through transcriptomics and metabolomics analysis

J Cui, H Tian, Y Qi, X Hu, S Li, W Zhang, Z Wei… - Ecotoxicology and …, 2024 - Elsevier
The utilisation of coated controlled-release fertilizers (CRFs) leads to the persistence of
residual plastic films in agricultural soils, posing a potential threat to crop health. This study …

[HTML][HTML] NADPH and mitochondrial quality control as targets for a circadian-based fasting and exercise therapy for the treatment of Parkinson's disease

WM Curtis, WA Seeds, MP Mattson, PC Bradshaw - Cells, 2022 - mdpi.com
Dysfunctional mitochondrial quality control (MQC) is implicated in the pathogenesis of
Parkinson's disease (PD). The improper selection of mitochondria for mitophagy increases …

ApoE expression in macrophages communicates immunometabolic signaling that controls hyperlipidemia‐driven hematopoiesis & inflammation via extracellular …

TA Phu, M Ng, NK Vu, AS Gao… - Journal of Extracellular …, 2023 - Wiley Online Library
While apolipoprotein E (apoE) expression by myeloid cells is recognized to control
inflammation, whether such benefits can be communicated via extracellular vesicles is not …

Targeting of chimeric antigen receptor T cell metabolism to improve therapeutic outcomes

PM Nanjireddy, SH Olejniczak… - Frontiers in …, 2023 - frontiersin.org
Genetically engineered chimeric antigen receptor (CAR) T cells can cure patients with
cancers that are refractory to standard therapeutic approaches. To date, adoptive cell …

Tumor energy metabolism: Implications for therapeutic targets

Y Hu, W Liu, WD Fang, Y Dong, H Zhang, Q Luo - Molecular Biomedicine, 2024 - Springer
Tumor energy metabolism plays a crucial role in the occurrence, progression, and drug
resistance of tumors. The study of tumor energy metabolism has gradually become an …

HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages

K Das Gupta, D Ramnath, JB von Pein… - Proceedings of the …, 2023 - pnas.org
The immune system must be able to respond to a myriad of different threats, each requiring
a distinct type of response. Here, we demonstrate that the cytoplasmic lysine deacetylase …

Inhibition of METTL3 in macrophages provides protection against intestinal inflammation

H Yin, Z Ju, X Zhang, W Zuo, Y Yang… - Cellular & Molecular …, 2024 - nature.com
Inflammatory bowel disease (IBD) is prevalent, and no satisfactory therapeutic options are
available because the mechanisms underlying its development are poorly understood. In …

Immunometabolism: a new dimension in immunotherapy resistance

C **ao, W **ong, Y Xu, J Zou, Y Zeng, J Liu, Y Peng… - Frontiers of …, 2023 - Springer
Immune checkpoint inhibitors (ICIs) have demonstrated unparalleled clinical responses and
revolutionized the paradigm of tumor treatment, while substantial patients remain …