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The pentose phosphate pathway in health and disease
The pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …
Metabolic reprogramming in cancer: Mechanisms and therapeutics
S Nong, X Han, Y **ang, Y Qian, Y Wei, T Zhang… - MedComm, 2023 - Wiley Online Library
Cancer cells characterized by uncontrolled growth and proliferation require altered
metabolic processes to maintain this characteristic. Metabolic reprogramming is a process …
metabolic processes to maintain this characteristic. Metabolic reprogramming is a process …
[HTML][HTML] Impact of microplastic residues from polyurethane films on crop growth: Unraveling insights through transcriptomics and metabolomics analysis
J Cui, H Tian, Y Qi, X Hu, S Li, W Zhang, Z Wei… - Ecotoxicology and …, 2024 - Elsevier
The utilisation of coated controlled-release fertilizers (CRFs) leads to the persistence of
residual plastic films in agricultural soils, posing a potential threat to crop health. This study …
residual plastic films in agricultural soils, posing a potential threat to crop health. This study …
[HTML][HTML] NADPH and mitochondrial quality control as targets for a circadian-based fasting and exercise therapy for the treatment of Parkinson's disease
Dysfunctional mitochondrial quality control (MQC) is implicated in the pathogenesis of
Parkinson's disease (PD). The improper selection of mitochondria for mitophagy increases …
Parkinson's disease (PD). The improper selection of mitochondria for mitophagy increases …
ApoE expression in macrophages communicates immunometabolic signaling that controls hyperlipidemia‐driven hematopoiesis & inflammation via extracellular …
While apolipoprotein E (apoE) expression by myeloid cells is recognized to control
inflammation, whether such benefits can be communicated via extracellular vesicles is not …
inflammation, whether such benefits can be communicated via extracellular vesicles is not …
Targeting of chimeric antigen receptor T cell metabolism to improve therapeutic outcomes
Genetically engineered chimeric antigen receptor (CAR) T cells can cure patients with
cancers that are refractory to standard therapeutic approaches. To date, adoptive cell …
cancers that are refractory to standard therapeutic approaches. To date, adoptive cell …
Tumor energy metabolism: Implications for therapeutic targets
Y Hu, W Liu, WD Fang, Y Dong, H Zhang, Q Luo - Molecular Biomedicine, 2024 - Springer
Tumor energy metabolism plays a crucial role in the occurrence, progression, and drug
resistance of tumors. The study of tumor energy metabolism has gradually become an …
resistance of tumors. The study of tumor energy metabolism has gradually become an …
HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages
The immune system must be able to respond to a myriad of different threats, each requiring
a distinct type of response. Here, we demonstrate that the cytoplasmic lysine deacetylase …
a distinct type of response. Here, we demonstrate that the cytoplasmic lysine deacetylase …
Inhibition of METTL3 in macrophages provides protection against intestinal inflammation
H Yin, Z Ju, X Zhang, W Zuo, Y Yang… - Cellular & Molecular …, 2024 - nature.com
Inflammatory bowel disease (IBD) is prevalent, and no satisfactory therapeutic options are
available because the mechanisms underlying its development are poorly understood. In …
available because the mechanisms underlying its development are poorly understood. In …
Immunometabolism: a new dimension in immunotherapy resistance
C **ao, W **ong, Y Xu, J Zou, Y Zeng, J Liu, Y Peng… - Frontiers of …, 2023 - Springer
Immune checkpoint inhibitors (ICIs) have demonstrated unparalleled clinical responses and
revolutionized the paradigm of tumor treatment, while substantial patients remain …
revolutionized the paradigm of tumor treatment, while substantial patients remain …