Role of biocatalysis in sustainable chemistry

RA Sheldon, JM Woodley - Chemical reviews, 2018 - ACS Publications
Based on the principles and metrics of green chemistry and sustainable development,
biocatalysis is both a green and sustainable technology. This is largely a result of the …

Continuous‐flow technology—a tool for the safe manufacturing of active pharmaceutical ingredients

B Gutmann, D Cantillo… - Angewandte Chemie …, 2015 - Wiley Online Library
In the past few years, continuous‐flow reactors with channel dimensions in the micro‐or
millimeter region have found widespread application in organic synthesis. The characteristic …

Flow chemistry—microreaction technology comes of age

KF Jensen - AIChE Journal, 2017 - Wiley Online Library
Over the past two decades, microreaction technology has matured from early devices and
concepts to encompass a wide range of commercial equipment and applications. This …

Quid pro flow

A Laybourn, K Robertson, AG Slater - Journal of the American …, 2023 - ACS Publications
How do you get into flow? We trained in flow chemistry during postdoctoral research and are
now applying it in new areas: materials chemistry, crystallization, and supramolecular …

A fully automated flow-based approach for accelerated peptide synthesis

AJ Mijalis, DA Thomas III, MD Simon, A Adamo… - Nature chemical …, 2017 - nature.com
Here we report a fully automated, flow-based approach to solid-phase polypeptide
synthesis, with amide bond formation in 7 seconds and total synthesis times of 40 seconds …

Flow chemistry syntheses of natural products

JC Pastre, DL Browne, SV Ley - Chemical Society Reviews, 2013 - pubs.rsc.org
The development and application of continuous flow chemistry methods for synthesis is a
rapidly growing area of research. In particular, natural products provide demanding …

The use of gases in flow synthesis

CJ Mallia, IR Baxendale - Organic Process Research & …, 2016 - ACS Publications
This review will highlight the potential benefits that can be leveraged by using flow chemistry
to allow gases to be used in research in a safer and more efficient way. An overview of the …

Process intensification

FJ Keil - Reviews in Chemical Engineering, 2018 - degruyter.com
Process intensification (PI) is a rapidly growing field of research and industrial development
that has already created many innovations in chemical process industry. PI is directed …

Supported catalysis in continuous‐flow microreactors

R Munirathinam, J Huskens… - Advanced synthesis & …, 2015 - Wiley Online Library
This review surveys the recent developments to perform heterogeneous catalysis in
continuous‐flow microreactors. Three different types, namely,(i) packed‐bed,(ii) monolithic …

Oscillatory flow reactors (OFRs) for continuous manufacturing and crystallization

T McGlone, NEB Briggs, CA Clark… - … Process Research & …, 2015 - ACS Publications
Continuous crystallization is an attractive approach for the delivery of consistent particles
with specified critical quality attributes (CQAs), which are attracting increased interest for the …