[HTML][HTML] Multiple neuronal populations control the eating behavior in Hydra and are responsive to microbial signals

C Giez, D Pinkle, Y Giencke, J Wittlieb, E Herbst… - Current Biology, 2023 - cell.com
Although recent studies indicate the impact of microbes on the central nervous systems and
behavior, it remains unclear how the relationship between the functionality of the nervous …

[HTML][HTML] Satiety controls behavior in Hydra through an interplay of pre-enteric and central nervous system-like neuron populations

C Giez, C Noack, E Sakib, LM Hofacker, U Repnik… - Cell Reports, 2024 - cell.com
Hunger and satiety can have an influence on decision-making, sensory processing, and
motor behavior by altering the internal state of the brain. This process necessitates the …

Systematic dissection of sequence features affecting binding specificity of a pioneer factor reveals binding synergy between FOXA1 and AP-1

C Xu, H Kleinschmidt, J Yang, EM Leith, J Johnson… - Molecular cell, 2024 - cell.com
Despite the unique ability of pioneer factors (PFs) to target nucleosomal sites in closed
chromatin, they only bind a small fraction of their genomic motifs. The underlying mechanism …

[HTML][HTML] Pressurized Hot Water Extraction of Mangosteen Pericarp and Its Associated Molecular Signatures in Endothelial Cells

SSY Tan, M Shanmugham, YL Chin, J An, CK Chua… - Antioxidants, 2023 - mdpi.com
The mangosteen (Garcinia mangostana L.) pericarp is known to be rich in potent bioactive
phytochemical compounds such as xanthones, which possess pharmacologically important …

The amyloid precursor protein regulates synaptic transmission at medial perforant path synapses

M Lenz, A Eichler, P Kruse, C Galanis… - Journal of …, 2023 - jneurosci.org
The perforant path provides the primary cortical excitatory input to the hippocampus.
Because of its important role in information processing and coding, entorhinal projections to …

[HTML][HTML] Multiomics with Evolutionary Computation to Identify Molecular and Module Biomarkers for Early Diagnosis and Treatment of Complex Disease

H Cheng, M Liang, Y Gao, W Zhao, WF Guo - Genes, 2025 - mdpi.com
It is important to identify disease biomarkers (DBs) for early diagnosis and treatment of
complex diseases in personalized medicine. However, existing methods integrating …

Laminin-α2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanisms

SG Martins, V Ribeiro, C Melo… - Life Science …, 2024 - life-science-alliance.org
LAMA2, coding for the laminin-α2 chain, is a crucial ECM component, particularly abundant
in skeletal muscle. Mutations in LAMA2 trigger the often-lethal LAMA2-congenital muscular …

Upregulation of inhibitor of DNA binding 1 and 3 is important for efficient thermogenic response in human adipocytes

R Arianti, BÁ Vinnai, R Alrifai, G Karadsheh… - Scientific Reports, 2024 - nature.com
Brown and beige adipocytes can be activated by β-adrenergic agonist via cAMP-dependent
signaling. Performing RNA-sequencing analysis in human cervical area-derived adipocytes …

Unravelling the role of long non-coding RNAs in modulating the Hedgehog pathway in cancer

SS Chandel, A Mishra, G Dubey, RP Singh… - … -Research and Practice, 2024 - Elsevier
Cancer is a multifactorial pathological condition characterized by uncontrolled cellular
proliferation, genomic instability, and evasion of regulatory mechanisms. It arises from the …

Application of transcriptomic profiling to investigate the toxicity mechanisms caused by dietary exposure of nanoplastics in fish

A Cuesta, C Espinosa, MA Esteban… - Aquatic Toxicology, 2023 - Elsevier
Nowadays, nanoplastics (NPs) are one of the main concerns regarding plastic pollution. The
increasing presence of plastic particles, fibers and fragments in the marine environment …