Why nanoparticles prefer liver macrophage cell uptake in vivo

W Ngo, S Ahmed, C Blackadar, B Bussin, Q Ji… - Advanced Drug Delivery …, 2022 - Elsevier
Effective delivery of therapeutic and diagnostic nanoparticles is dependent on their ability to
accumulate in diseased tissues. However, most nanoparticles end up in liver macrophages …

Drug delivery and nanoparticles: applications and hazards

WH De Jong, PJA Borm - International journal of nanomedicine, 2008 - Taylor & Francis
The use of nanotechnology in medicine and more specifically drug delivery is set to spread
rapidly. Currently many substances are under investigation for drug delivery and more …

Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles

G Oberdörster, E Oberdörster… - Environmental health …, 2005 - ehp.niehs.nih.gov
Although humans have been exposed to airborne nanosized particles (NSPs;< 100 nm)
throughout their evolutionary stages, such exposure has increased dramatically over the last …

Physiologic upper limits of pore size of different blood capillary types and another perspective on the dual pore theory of microvascular permeability

H Sarin - Journal of angiogenesis research, 2010 - Springer
Background Much of our current understanding of microvascular permeability is based on
the findings of classic experimental studies of blood capillary permeability to various-sized …

Cancer treatment and toxicity outlook of nanoparticles

M Sharma, P Thakur, P Gaur, GM Rani, S Rustagi… - Environmental …, 2023 - Elsevier
Diversified nanosystems with tunable physicochemical attributes have emerged as potential
solution to globally devastating cancer by offering novel possibilities for improving the …

[책][B] Handbook of pharmaceutical controlled release technology

DL Wise - 2000 - taylorfrancis.com
The Handbook of Pharmaceutical Controlled Release Technology reviews the design,
fabrication, methodology, administration, and classifications of various drug delivery …

Acute toxicological impact of nano-and submicro-scaled zinc oxide powder on healthy adult mice

B Wang, W Feng, M Wang, T Wang, Y Gu… - Journal of Nanoparticle …, 2008 - Springer
In this work, the acute oral toxicity of 20-and 120-nm ZnO powder at doses of 1-, 2-, 3-, 4-, 5-
g/kg body weight was evaluated referred to the OECD guidelines for testing of chemicals. As …

Spinal cord injury: a review of current therapy, future treatments, and basic science frontiers

AK Varma, A Das, G Wallace, J Barry… - Neurochemical …, 2013 - Springer
The incidence of acute and chronic spinal cord injury (SCI) in the United States is more than
10,000 per year, resulting in 720 cases per million persons enduring permanent disability …

Drug delivery systems based on nanoparticles and related nanostructures

AVV Nikezić, AM Bondžić, VM Vasić - European Journal of Pharmaceutical …, 2020 - Elsevier
A new approach to drug design based on nanoparticles and related nanostructures for
effective drug delivery, is of great importance in future medical treatment, especially for …

Therapeutic potential of nanoparticulate systems for macrophage targeting

F Chellat, Y Merhi, A Moreau - Biomaterials, 2005 - Elsevier
The use of non-viral nanoparticulate systems for the delivery of therapeutic agents is
receiving considerable attention for medical and pharmaceutical applications. This …