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Networking brainstem and basal ganglia circuits for movement
S Arber, RM Costa - Nature Reviews Neuroscience, 2022 - nature.com
The execution and learning of diverse movements involve neuronal networks distributed
throughout the nervous system. The brainstem and basal ganglia are key for processing …
throughout the nervous system. The brainstem and basal ganglia are key for processing …
Cell and circuit complexity of the external globus pallidus
CD Courtney, A Pamukcu, CS Chan - Nature neuroscience, 2023 - nature.com
The external globus pallidus (GPe) of the basal ganglia has been underappreciated owing
to poor understanding of its cells and circuits. It was assumed that the GPe consisted of a …
to poor understanding of its cells and circuits. It was assumed that the GPe consisted of a …
The indirect pathway of the basal ganglia promotes transient punishment but not motor suppression
Optogenetic stimulation of Adora2a receptor-expressing spiny projection neurons (A2A-
SPNs) in the striatum drives locomotor suppression and transient punishment, results …
SPNs) in the striatum drives locomotor suppression and transient punishment, results …
Connectivity and functionality of the globus pallidus externa under normal conditions and Parkinson's disease
The globus pallidus externa (GPe) functions as a central hub in the basal ganglia for
processing motor and non-motor information through the creation of complex connections …
processing motor and non-motor information through the creation of complex connections …
[HTML][HTML] Functional diversity for body actions in the mesencephalic locomotor region
MJ Ferreira-Pinto, H Kanodia, A Falasconi, M Sigrist… - Cell, 2021 - cell.com
The mesencephalic locomotor region (MLR) is a key midbrain center with roles in
locomotion. Despite extensive studies and clinical trials aimed at therapy-resistant …
locomotion. Despite extensive studies and clinical trials aimed at therapy-resistant …
[HTML][HTML] A disynaptic circuit in the globus pallidus controls locomotion inhibition
A Aristieta, M Barresi, SA Lindi, G Barriere, G Courtand… - Current Biology, 2021 - cell.com
The basal ganglia (BG) inhibit movements through two independent circuits: the striatal
neuron-indirect and the subthalamic nucleus-hyperdirect pathways. These pathways exert …
neuron-indirect and the subthalamic nucleus-hyperdirect pathways. These pathways exert …
Divergent pallidal pathways underlying distinct Parkinsonian behavioral deficits
V Lilascharoen, EHJ Wang, N Do, SC Pate… - Nature …, 2021 - nature.com
The basal ganglia regulate a wide range of behaviors, including motor control and cognitive
functions, and are profoundly affected in Parkinson's disease (PD). However, the functional …
functions, and are profoundly affected in Parkinson's disease (PD). However, the functional …
[HTML][HTML] Differential synaptic input to external globus pallidus neuronal subpopulations in vivo
M Ketzef, G Silberberg - Neuron, 2021 - cell.com
The rodent external globus pallidus (GPe) contains two main neuronal subpopulations,
prototypic and arkypallidal cells, which differ in their cellular properties. Their functional …
prototypic and arkypallidal cells, which differ in their cellular properties. Their functional …
A review of temporal interference, nanoparticles, ultrasound, gene therapy, and designer receptors for Parkinson disease
AD Currie, JK Wong, MS Okun - npj Parkinson's Disease, 2024 - nature.com
In this review, we summarize preclinical and clinical trials investigating innovative
neuromodulatory approaches for Parkinson disease (PD) motor symptom management. We …
neuromodulatory approaches for Parkinson disease (PD) motor symptom management. We …
Architecture of the subthalamic nucleus
AA Prasad, Å Wallén-Mackenzie - Communications Biology, 2024 - nature.com
The subthalamic nucleus (STN) is a major neuromodulation target for the alleviation of
neurological and neuropsychiatric symptoms using deep brain stimulation (DBS). STN-DBS …
neurological and neuropsychiatric symptoms using deep brain stimulation (DBS). STN-DBS …