Depression is a complex disorder that takes an enormous toll on individual health. As
affected individuals display a wide variation in their clinical symptoms, the precise neural …

Alzheimer's disease (AD) is known as the most fatal chronic neurodegenerative disease in
adults along with progressive loss of memory and other cognitive function disorders. Cyclin …

In order to thrive, animals must be able to recognize aversive and appetitive stimuli within
the environment and subsequently initiate appropriate behavioral responses. This …

A central goal in understanding brain function is to link specific cell populations to
behavioral outputs. In recent years, the selective targeting of specific neural circuits has …

The advent of optogenetics and chemogenetics has revolutionized the study of neural circuit
mechanisms of behavioral dysregulation in psychiatric disease. These powerful …

Major depressive disorder (MDD) and its treatment are challenges for global health.
Optogenetics and chemogenetics are driving MDD research forward by unveiling causal …

Studies over the past several decades have identified numerous epigenetic mechanisms
associated with pathological states in psychiatric and neurological disease. Until recently …

Recent studies have implicated epigenetic remodeling in brain reward regions following
psychostimulant or stress exposure. It has only recently become possible to target a given …

Dopamine neurons in the ventral tegmental area (VTA) are powerful regulators of
depression-related behavior. Dopamine neuron activity is altered in chronic stress-based …

The cAMP and cAMP-dependent protein kinase A (PKA) signaling cascade is a ubiquitous
pathway acting downstream of multiple neuromodulators. We found that the phosphorylation …