Dynamic regulation of nucleosome positioning in the human genome
The positioning of nucleosomes with respect to DNA plays an important role in regulating
transcription. However, nucleosome map** has been performed for only limited genomic …
transcription. However, nucleosome map** has been performed for only limited genomic …
Nucleosome positioning in Saccharomyces cerevisiae
A Jansen, KJ Verstrepen - Microbiology and molecular biology …, 2011 - Am Soc Microbiol
The DNA of eukaryotic cells is spooled around large histone protein complexes, forming
nucleosomes that make up the basis for a high-order packaging structure called chromatin …
nucleosomes that make up the basis for a high-order packaging structure called chromatin …
Characterization of enhancer function from genome-wide analyses
GA Maston, SG Landt, M Snyder… - Annual review of …, 2012 - annualreviews.org
There has been a recent surge in the use of genome-wide methodologies to identify and
annotate the transcriptional regulatory elements in the human genome. Here we review …
annotate the transcriptional regulatory elements in the human genome. Here we review …
A region of the human HOXD cluster that confers polycomb-group responsiveness
CJ Woo, PV Kharchenko, L Daheron, PJ Park… - Cell, 2010 - cell.com
Polycomb group (PcG) proteins are essential for accurate axial body patterning during
embryonic development. PcG-mediated repression is conserved in metazoans and is …
embryonic development. PcG-mediated repression is conserved in metazoans and is …
Nucleosome positioning signals in genomic DNA
HE Peckham, RE Thurman, Y Fu… - Genome …, 2007 - genome.cshlp.org
Although histones can form nucleosomes on virtually any genomic sequence, DNA
sequences show considerable variability in their binding affinity. We have used DNA …
sequences show considerable variability in their binding affinity. We have used DNA …
Genome-wide nucleosome map and cytosine methylation levels of an ancient human genome
Epigenetic information is available from contemporary organisms, but is difficult to track back
in evolutionary time. Here, we show that genome-wide epigenetic information can be …
in evolutionary time. Here, we show that genome-wide epigenetic information can be …
[HTML][HTML] Epigenetic changes in fetal hypothalamic energy regulating pathways are associated with maternal undernutrition and twinning
G Begum, A Stevens, EB Smith, K Connor… - The FASEB …, 2012 - ncbi.nlm.nih.gov
Undernutrition during pregnancy is implicated in the programming of offspring for the
development of obesity and diabetes. We hypothesized that maternal programming causes …
development of obesity and diabetes. We hypothesized that maternal programming causes …
Nucleosomal occupancy changes locally over key regulatory regions during cell differentiation and reprogramming
Chromatin structure determines DNA accessibility. We compare nucleosome occupancy in
mouse and human embryonic stem cells (ESCs), induced-pluripotent stem cells (iPSCs) and …
mouse and human embryonic stem cells (ESCs), induced-pluripotent stem cells (iPSCs) and …
Predicting human nucleosome occupancy from primary sequence
S Gupta, J Dennis, RE Thurman… - PLoS computational …, 2008 - journals.plos.org
Nucleosomes are the fundamental repeating unit of chromatin and comprise the structural
building blocks of the living eukaryotic genome. Micrococcal nuclease (MNase) has long …
building blocks of the living eukaryotic genome. Micrococcal nuclease (MNase) has long …
Epigenetic silencing in Friedreich ataxia is associated with depletion of CTCF (CCCTC-binding factor) and antisense transcription
I De Biase, YK Chutake, PM Rindler, SI Bidichandani - PloS one, 2009 - journals.plos.org
Background Over 15 inherited diseases are caused by expansion of triplet-repeats.
Friedreich ataxia (FRDA) patients are homozygous for an expanded GAA triplet-repeat …
Friedreich ataxia (FRDA) patients are homozygous for an expanded GAA triplet-repeat …