The development of cancer is due to the accumulation of multiple somatic mutations and in
some cases due to germline mutations, which occur in malignancies such as retinoblastoma …

The gene known as neu, erbB-2, or HER-2 is among those most frequently altered in human
cancer, neu was first identified as a transforming gene activated in chemically induced rat …

Background. Although there are many reported prognostic indicators for pulmonary
adenocarcinoma, the clinicopathologic characteristics and prognostic factors of early stage …

To evaluate the role of Akt/PKB in non-small cell lung cancer (NSCLC) survival, we analyzed
NSCLC cell lines that differed in tumor histology as well as p53, Rb, and K-ras status …

Study objectives To provide a systematic overview of the literature investigating patient and
tumor factors that are predictive of survival for patients with non-small cell lung cancer …

The proto-oncogene designated erb B2 or HER2 encodes a 185-kilodalton transmembrane
tyrosine kinase (p185 erb B2), whose overexpression has been correlated with a poor …

Overexpression of the erbB‐2 gene contributes to aggressive behavior of various human
adenocarcinomas, including breast cancer, through an unknown molecular mechanism. The …

The HER2 protooncogene encodes a receptor tyrosine kinase, p185 HER2. The
overexpression of p185 HER2 has been associated with a worsened prognosis in certain …

The duration of survival in early-stage lung cancer (stages I and II) varies between reports in
the literature. Several reasons account for this: patient population heterogeneity …

The prognostic role of epidermal growth factor receptor (EGFR) and HER2-neu remains
controversial in patients with non-small cell lung cancer (NSCLC). We studied the …