Molecular physiology of Arc/Arg3. 1: The oligomeric state hypothesis of synaptic plasticity
MS Eriksen, CR Bramham - Acta Physiologica, 2022 - Wiley Online Library
The immediate early gene, Arc, is a pivotal regulator of synaptic plasticity, memory, and
cognitive flexibility. But what is Arc protein? How does it work? Inside the neuron, Arc is a …
cognitive flexibility. But what is Arc protein? How does it work? Inside the neuron, Arc is a …
Intercellular communication in the nervous system goes viral
Viruses and transposable elements are major drivers of evolution and make up over half the
sequences in the human genome. In some cases, these elements are co-opted to perform …
sequences in the human genome. In some cases, these elements are co-opted to perform …
Arc controls alcohol cue relapse by a central amygdala mechanism
R Pagano, A Salamian, J Zielinski, A Beroun… - Molecular …, 2023 - nature.com
Alcohol use disorder (AUD) is a chronic and fatal disease. The main impediment of the AUD
therapy is a high probability of relapse to alcohol abuse even after prolonged abstinence …
therapy is a high probability of relapse to alcohol abuse even after prolonged abstinence …
The C‐terminal domains of the NMDA receptor: How intrinsically disordered tails affect signalling, plasticity and disease
XL Warnet, H Bakke Krog… - European Journal of …, 2021 - Wiley Online Library
NMDA receptors are part of the ionotropic glutamate receptor family, and are crucial for
neurotransmission and memory. At the cellular level, the effects of activating these receptors …
neurotransmission and memory. At the cellular level, the effects of activating these receptors …
Arc self‐association and formation of virus‐like capsids are mediated by an N‐terminal helical coil motif
Activity‐regulated cytoskeleton‐associated protein (Arc) is a protein interaction hub with
diverse roles in intracellular neuronal signaling, and important functions in neuronal …
diverse roles in intracellular neuronal signaling, and important functions in neuronal …
Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins
Arc, a neuronal gene that is critical for synaptic plasticity, originated through the
domestication of retrotransposon Gag genes and mediates intercellular messenger RNA …
domestication of retrotransposon Gag genes and mediates intercellular messenger RNA …
Mechanisms and functions of activity-regulated cytoskeleton-associated protein in synaptic plasticity
Y Chen, X Wang, B **ao, Z Luo, H Long - Molecular Neurobiology, 2023 - Springer
Activity-regulated cytoskeleton-associated protein (Arc) is one of the most important
regulators of cognitive functions in the brain regions. As a hub protein, Arc plays different …
regulators of cognitive functions in the brain regions. As a hub protein, Arc plays different …
Detection of Arc/Arg3.1 oligomers in rat brain: constitutive and synaptic activity-evoked dimer expression in vivo
TF Mergiya, JET Gundersen, T Kanhema… - Frontiers in Molecular …, 2023 - frontiersin.org
The immediate early gene product activity-regulated cytoskeleton-associated protein (Arc or
Arg3. 1) is a major regulator of long-term synaptic plasticity with critical roles in postnatal …
Arg3. 1) is a major regulator of long-term synaptic plasticity with critical roles in postnatal …
Arc weakens synapses by dispersing AMPA receptors from postsynaptic density via modulating PSD phase separation
In response to stimuli, the immediate early gene product Arc can acutely down-regulate
synaptic strength by removing AMPA receptors (AMPARs) from synapses and thus regulate …
synaptic strength by removing AMPA receptors (AMPARs) from synapses and thus regulate …
High-affinity anti-Arc nanobodies provide tools for structural and functional studies
Activity-regulated cytoskeleton-associated protein (Arc) is a multidomain protein of retroviral
origin with a vital role in the regulation of synaptic plasticity and memory formation in …
origin with a vital role in the regulation of synaptic plasticity and memory formation in …