Molecular physiology of Arc/Arg3. 1: The oligomeric state hypothesis of synaptic plasticity

MS Eriksen, CR Bramham - Acta Physiologica, 2022 - Wiley Online Library
The immediate early gene, Arc, is a pivotal regulator of synaptic plasticity, memory, and
cognitive flexibility. But what is Arc protein? How does it work? Inside the neuron, Arc is a …

Intercellular communication in the nervous system goes viral

MP Hantak, J Einstein, RB Kearns, JD Shepherd - Trends in neurosciences, 2021 - cell.com
Viruses and transposable elements are major drivers of evolution and make up over half the
sequences in the human genome. In some cases, these elements are co-opted to perform …

Arc controls alcohol cue relapse by a central amygdala mechanism

R Pagano, A Salamian, J Zielinski, A Beroun… - Molecular …, 2023 - nature.com
Alcohol use disorder (AUD) is a chronic and fatal disease. The main impediment of the AUD
therapy is a high probability of relapse to alcohol abuse even after prolonged abstinence …

The C‐terminal domains of the NMDA receptor: How intrinsically disordered tails affect signalling, plasticity and disease

XL Warnet, H Bakke Krog… - European Journal of …, 2021 - Wiley Online Library
NMDA receptors are part of the ionotropic glutamate receptor family, and are crucial for
neurotransmission and memory. At the cellular level, the effects of activating these receptors …

Arc self‐association and formation of virus‐like capsids are mediated by an N‐terminal helical coil motif

MS Eriksen, O Nikolaienko, EI Hallin… - The FEBS …, 2021 - Wiley Online Library
Activity‐regulated cytoskeleton‐associated protein (Arc) is a protein interaction hub with
diverse roles in intracellular neuronal signaling, and important functions in neuronal …

Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins

S Erlendsson, DR Morado, HB Cullen… - Nature …, 2020 - nature.com
Arc, a neuronal gene that is critical for synaptic plasticity, originated through the
domestication of retrotransposon Gag genes and mediates intercellular messenger RNA …

Mechanisms and functions of activity-regulated cytoskeleton-associated protein in synaptic plasticity

Y Chen, X Wang, B **ao, Z Luo, H Long - Molecular Neurobiology, 2023 - Springer
Activity-regulated cytoskeleton-associated protein (Arc) is one of the most important
regulators of cognitive functions in the brain regions. As a hub protein, Arc plays different …

Detection of Arc/Arg3.1 oligomers in rat brain: constitutive and synaptic activity-evoked dimer expression in vivo

TF Mergiya, JET Gundersen, T Kanhema… - Frontiers in Molecular …, 2023 - frontiersin.org
The immediate early gene product activity-regulated cytoskeleton-associated protein (Arc or
Arg3. 1) is a major regulator of long-term synaptic plasticity with critical roles in postnatal …

Arc weakens synapses by dispersing AMPA receptors from postsynaptic density via modulating PSD phase separation

X Chen, B Jia, Y Araki, B Liu, F Ye, R Huganir… - Cell Research, 2022 - nature.com
In response to stimuli, the immediate early gene product Arc can acutely down-regulate
synaptic strength by removing AMPA receptors (AMPARs) from synapses and thus regulate …

High-affinity anti-Arc nanobodies provide tools for structural and functional studies

S Markússon, EI Hallin, HJ Bustad, A Raasakka, J Xu… - Plos one, 2022 - journals.plos.org
Activity-regulated cytoskeleton-associated protein (Arc) is a multidomain protein of retroviral
origin with a vital role in the regulation of synaptic plasticity and memory formation in …