A randomized controlled trial is a prospective, comparative, quantitative study/experiment
performed under controlled conditions with random allocation of interventions to comparison …

There is considerable enthusiasm about the prospect that artificial intelligence (AI) will help
to improve the safety and efficacy of health services and the efficiency of health systems. To …

The foundations of research ethics are riven with fault lines emanating from a fear that if
research is too closely connected to weighty social purposes an imperative to advance the …

OBJECTIVES: To identify research priorities in the management, pathophysiology, and host
response of coronavirus disease 2019 in critically ill patients. DESIGN: The Surviving Sepsis …

Digital research methodologies are driving a revolution in health technology but do not yet
fully engage diverse and historically underrepresented populations. In this paper, we …

Secondary analysis of digital psychological data (DPD) is an increasingly popular method
for behavioral health research. Under current practices, secondary research does not …

Sharing research data has great potential to benefit science and society. However, data
sharing is still not common practice. Since public research funding agencies have a …

Forty years ago, the Belmont Report counseled that a “systematic, nonarbitrary analysis of
risks and benefits” is vital to ensuring the ethical appropriateness of research with human …

Phase I healthy volunteer trials test the safety and tolerability of investigational
pharmaceuticals. In them, participants are exposed to study‐drug risks without the possibility …

Background Observational studies using large-scale databases and biobanks help improve
prevention and treatment of sudden cardiac arrest (SCA) but the lack of guidance on data …