Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of
Parkinson's disease (PD) is now twenty-five years old, it still represents a milestone in PD …

Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars
compacta and subsequent reduction of dopamine levels in striatum are associated with …

The discovery of genetic forms of Parkinson's disease (PD) has highlighted the importance
of the autophagy/lysosomal and mitochondrial/oxidative stress pathways in disease …

The neuropathological hallmarks of Parkinson's disease (PD) are the degeneration and
death of dopamine‐producing neurons in the ventral midbrain, the widespread …

The aggregation of α-synuclein (α-syn) has been implicated in the pathogenesis of many
neurodegenerative disorders, including Parkinson's disease (PD), dementia with Lewy …

Background Parkinson's disease (PD) is characterized by degeneration of dopaminergic
neurons in the substantia nigra pars compacta (SNpc), accompanied by accumulation of α …

Synapse loss is an early feature shared by many neurodegenerative diseases, and it
represents the major correlate of cognitive impairment. Recent studies reveal that microglia …

Since the initial identification of alpha-synuclein (α-syn) at the synapse, numerous studies
demonstrated that α-syn is a key player in the etiology of Parkinson's disease (PD) and other …

Dopamine transporter (DAT) single-photon emission tomography (SPECT) with (123)
Ioflupane is a widely used diagnostic tool for patients with suspected parkinsonian …

The loss of dopaminergic neurons of the nigrostriatal system underlies the onset of the
typical motor symptoms of Parkinson's disease (PD). Lewy bodies (LB) and Lewy neurites …