Abstract Topoisomerase IB (Top1), a subcategory of DNA topoisomerase enzymes is
expressed much higher in several tumor cells. Therefore, modulating the activity of Top1 in …

Over the past years, impressive progress has been made on the development of the
chemoselective and direct formation of carbon–carbon and carbon–heteroatom bonds …

DNA topoisomerases I and II (Top1 and Top2) are established molecular targets of
anticancer drugs. 1-5 Mammalian somatic cells express six topoisomerase genes: two TOP1 …

As a consequence of their intrinsic advantageous properties, luminogens that show
aggregation‐induced emission (AIEgens) have received increasing global interest for a …

An electrooxidative direct arylsulfonlylation of ynones with sulfinic acids via a radical tandem
cyclization strategy has been developed for the construction of sulfonated indenones under …

G-quadruplexes are noncanonical four-stranded DNA secondary structures. MYC is a
master oncogene and the G-quadruplex formed in the MYC promoter functions as a …

The Cu (I)-catalyzed annulation–halotrifluoromethylation and cyanotrifluoromethylation of
enynones have been established, enabling multibond formations of the synthesis of …

A new electrochemically induced three-component annulation-halosulfonylation of 1, 6-
enynes has been developed for stereoselective synthesis of 33 examples of 1-indanones …

Carbon monoxide is an indispensable C1 building block that has been recognized as a
potent feedstock for synthesizing carbonyl-containing molecules. Carbonylative reactions …

The reactions of cyclic anhydrides acting dually as acylating agents and C-nucleophiles in
stereoselective annulation reactions provide efficient one-step synthesis of polysubstituted …