Thanks to recent improvements in NMR spectrometer hardware and pulse sequence design,
modern 13C NMR has become a useful tool for biomolecular applications. The complete …

The prevalence of intrinsically disordered protein regions, particularly in eukaryotic proteins,
and their clear functional advantages for signaling and gene regulation have created an …

Implementation of a new algorithm, SMILE, is described for reconstruction of non-uniformly
sampled two-, three-and four-dimensional NMR data, which takes advantage of the known …

Chemical shifts contain important site-specific information on the structure and dynamics of
proteins. Deviations from statistical average values, known as random coil chemical shifts …

Intrinsically disordered proteins (IDPs) or regions of intrinsic disorder in otherwise folded
proteins (IDRs) play important roles in many different biological processes, including …

Thanks to recent improvements in NMR instrumentation, pulse sequence design, and
sample preparation, a panoply of new NMR tools has become available for atomic …

Expansions of polyglutamine (polyQ) tracts in nine different proteins cause a family of
neurodegenerative disorders called polyQ diseases. Because polyQ tracts are potential …

The multi-domain transcriptional coactivators CBP/p300 integrate a multitude of signaling
inputs, interacting with more than 400 proteins via one or more of their globular domains …

Intrinsically disordered proteins (IDPs) are getting more and more interest of the scientific
community. Nuclear magnetic resonance (NMR) is often a technique of choice for these …

Here, we present a structural and dynamic description of CBP-ID4 at atomic resolution. ID4
is the fourth intrinsically disordered linker of CREB-binding protein (CBP). In spite of the …