ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …

The endoplasmic reticulum (ER) is the largest organelle in cells and has fundamental
functions, such as folding, processing, and trafficking of proteins, cellular metabolism, and …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines are
effective at protecting from severe disease, but the protective antibodies wane rapidly even …

Beginning with the earliest studies of autophagy in cancer, there have been indications that
autophagy can both promote and inhibit cancer growth and progression; autophagy …

The regulation of antibody production is linked to the generation and maintenance of
plasmablasts and plasma cells from their B cell precursors. Plasmablasts are the rapidly …

Mechanisms of selective autophagy of the ER, known as ER-phagy, require molecular
delineation, particularly in vivo. It is unclear how these events control ER proteostasis and …

Across all branches of the immune system, the process of autophagy is fundamentally
important in cellular development, function and homeostasis. Strikingly, this evolutionarily …

Autophagy, a cellular waste disposal process, has well-established tumor-suppressive
properties. New studies indicate that, in addition to its cell-autonomous anti-tumorigenic …

Autophagy (self-eating) is a conserved cellular degradation process that plays important
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …

Autophagy has broad functions in immunity, ranging from cell-autonomous defence to
coordination of complex multicellular immune responses. The successful resolution of …