The fact that not all individuals exposed to the same environmental risk factors develop
obesity supports the hypothesis of the existence of underlying genetic and epigenetic …

Objective: Rapid advances of high-throughput technologies and wide adoption of electronic
health records (EHRs) have led to fast accumulation of–omic and EHR data. These …

DNA methylation is an epigenetic mark that has suspected regulatory roles in a broad range
of biological processes and diseases. The technology is now available for studying DNA …

Heritable epigenetic polymorphisms, such as differential cytosine methylation, can underlie
phenotypic variation,. Moreover, wild strains of the plant Arabidopsis thaliana differ in many …

Background The identification and characterisation of differentially methylated regions
(DMRs) between phenotypes in the human genome is of prime interest in epigenetics. We …

Mutations in the epigenetic modifiers DNMT3A and TET2 non-randomly co-occur in
lymphoma and leukemia despite their epistasis in the methylation–hydroxymethylation …

The complex pathobiology underlying cardiovascular diseases (CVDs) has yet to be
explained. Aberrant epigenetic changes may result from alterations in enzymatic activities …

Understanding the intratumoral heterogeneity of hepatocellular carcinoma is instructive for
develo** personalized therapy and identifying molecular biomarkers. Here we applied …

Background Methylation of high-density CpG regions known as CpG Islands (CGIs) has
been widely described as a mechanism associated with gene expression regulation …

The human disease methylation database (DiseaseMeth, http://bioinfo. hrbmu. edu.
cn/diseasemeth/) is an interactive database that aims to present the most complete …