Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

In addition to their many functions in the healthy central nervous system (CNS), astrocytes
respond to CNS damage and disease through a process called “reactivity.” Recent evidence …

The cognitive abilities of humans are distinctive among primates, but their molecular and
cellular substrates are poorly understood. We used comparative single-nucleus …

Parkinson's disease (PD) is a gradually worsening neurodegenerative disorder affecting the
nervous system, marked by a slow progression and varied symptoms. It is the second most …

An accumulating body of evidence suggests that the bacterium Akkermansia muciniphila
exhibits positive systemic effects on host health, mainly by improving immunological and …

The pathogenesis and clinical heterogeneity of Parkinson's disease (PD) have been
evaluated from molecular, pathophysiological, and clinical perspectives. High-throughput …

Amyotrophic lateral sclerosis (ALS) has substantial heritability, in part shared with fronto-
temporal dementia (FTD). We show that ALS heritability is enriched in splicing variants and …

Epigenetics defines changes in cell function without involving alterations in DNA sequence.
Neuroepigenetics bridges neuroscience and epigenetics by regulating gene expression in …

Parkinson's Disease (PD) is the second most common neurodegenerative disorder. The
pathological hallmark of PD is loss of dopaminergic neurons and the presence of …

Genome-wide association studies (GWASs) have identified numerous susceptibility loci for
Parkinson's disease (PD), but its genetic architecture remains underexplored in populations …