The crosstalk of CD8+ T cells and ferroptosis in cancer

Z Lin, S Zou, K Wen - Frontiers in Immunology, 2024 - frontiersin.org
Ferroptosis is an iron-dependent, novel form of programmed cell death characterized by
lipid peroxidation and glutathione depletion and is widespread in a variety of diseases …

Targeting cGAS/STING signaling-mediated myeloid immune cell dysfunction in TIME

V Kumar, C Bauer, JH Stewart IV - Journal of biomedical science, 2023 - Springer
Myeloid immune cells (MICs) are potent innate immune cells serving as first responders to
invading pathogens and internal changes to cellular homeostasis. Cancer is a stage of …

Diffuse large B-cell lymphoma microenvironment displays a predominant macrophage infiltrate marked by a strong inflammatory signature

L Serna, P Azcoaga, M Brahmachary… - Frontiers in …, 2023 - frontiersin.org
Inflammasomes are cytosolic signaling hubs that promote the inflammatory response (ie an
immune reaction to counteract threats in physiological conditions). Their potential role in …

Hypermethylation loci of ZNF671, IRF8, and OTX1 as potential urine-based predictive biomarkers for bladder cancer

YH Jiang, YS Liu, YC Wei, JF Jhang, HC Kuo… - Diagnostics, 2024 - mdpi.com
Bladder cancer (BCa) is a significant health issue and poses a healthcare burden on
patients, highlighting the importance of an effective detection method. Here, we developed a …

Should I stay or should I go? Spatio-temporal control of cellular anchorage by hematopoietic factors orchestrates tumor metastatic cascade

V Marabitti, I Caruana, F Nazio - Molecular Cancer, 2023 - Springer
The term “metastatic cascade” defines a process whereby few tumor cells complete a
sequence of steps to leave the primary tumor to reach one or more sites elsewhere in the …

Immune classification and immune landscape analysis of triple-negative breast cancer

S Hu, X Qu, Y Jiao, J Hu, B Wang - Frontiers in Genetics, 2021 - frontiersin.org
Background: To classify triple-negative breast cancer (TNBC) immunoty** using the public
database, analyze the differences between subtypes in terms of clinical characteristics and …

Comprehensive analysis of immune subtypes reveals the prognostic value of cytotoxicity and FAP+ fibroblasts in stomach adenocarcinoma

X Wang, S Hui, C Tan, Z Deng, X Wang… - Cancer Immunology …, 2023 - Springer
Background The heterogeneity limits the effective application of immune checkpoint
inhibitors for patients with stomach adenocarcinoma (STAD). Precise immunoty** can …

Immunohistochemical Investigation into Protein Expression Patterns of FOXO4, IRF8 and LEF1 in Canine Osteosarcoma

S Brot, J Cobb, AA Alibhai, J Jackson-Oxley, M Haque… - Cancers, 2024 - mdpi.com
Simple Summary There have been limited advances in the diagnosis, prognosis, and
treatment of both canine and human osteosarcoma (OSA), the most common type of primary …

The most likely but largely ignored triggering factor for breast (or all) cancer invasion

Y Man, C Mannion, A Stojadinovic… - Journal of …, 2023 - pmc.ncbi.nlm.nih.gov
Breast cancer development and progression are believed to be a sequential process, from
normal to hyperplastic, to in situ, and to invasive and metastatic stages. Given that over 90 …

[HTML][HTML] IRF8: mechanism of action and health implications

HR Moorman, Y Reategui, DB Poschel, K Liu - Cells, 2022 - mdpi.com
Interferon regulatory factor 8 (IRF8) is a transcription factor of the IRF protein family. IRF8
was originally identified as an essentialfactor for myeloid cell lineage commitment and …