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Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …
Potential inhibitors targeting papain-like protease of SARS-CoV-2: two birds with one stone
H Jiang, P Yang, J Zhang - Frontiers in chemistry, 2022 - frontiersin.org
Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), the pathogen of the
Coronavirus disease-19 (COVID-19), is still devastating the world causing significant chaos …
Coronavirus disease-19 (COVID-19), is still devastating the world causing significant chaos …
Dual synergistic inhibition of COX and LOX by potential chemicals from Indian daily spices investigated through detailed computational studies
Abstract Cyclooxygenase (COX) and Lipoxygenase (LOX) are essential enzymes for
arachidonic acid (AA) to eicosanoids conversion. These AA-derived eicosanoids are …
arachidonic acid (AA) to eicosanoids conversion. These AA-derived eicosanoids are …
Characterization of the binding of MRTX1133 as an avenue for the discovery of potential KRASG12D inhibitors for cancer therapy
The Kirsten rat sarcoma (KRAS) oncoprotein has been on drug hunters list for decades now.
Initially considered undruggable, recent advances have successfully broken the **x through …
Initially considered undruggable, recent advances have successfully broken the **x through …
[HTML][HTML] Repurposing of phytomedicine-derived bioactive compounds with promising anti-SARS-CoV-2 potential: Molecular docking, MD simulation and drug-likeness …
In view of the potential of traditional plant-based remedies (or phytomedicines) in the
management of COVID-19, the present investigation was aimed at finding novel anti-SARS …
management of COVID-19, the present investigation was aimed at finding novel anti-SARS …
[HTML][HTML] Identification of bioactive molecules from Triphala (Ayurvedic herbal formulation) as potential inhibitors of SARS-CoV-2 main protease (Mpro) through …
Severe acute respiratory syndrome coronavirus disease (SARS-CoV-2) induced coronavirus
disease 2019 (COVID-19) pandemic is the present worldwide health emergency. The global …
disease 2019 (COVID-19) pandemic is the present worldwide health emergency. The global …
Discovery of Potential KRAS‐SOS1 Inhibitors from South African Natural Compounds: An In silico Approach
For decades the direct targeting of KRAS as a driver of non‐small cell lung cancer,
colorectal and pancreatic cancers as well as the inhibition of the RAF‐MEK‐ERK pathway …
colorectal and pancreatic cancers as well as the inhibition of the RAF‐MEK‐ERK pathway …
Utilizing Andrographis paniculata leaves and roots by effective usage of the bioactive andrographolide and its nanodelivery: investigation of antikindling and …
R Baru Venkata, DSNBK Prasanth, PK Pasala… - Frontiers in …, 2023 - frontiersin.org
To valorise the bioactive constituents abundant in leaves and other parts of medicinal plants
with the objective to minimize the plant-based wastes, this study was undertaken. The main …
with the objective to minimize the plant-based wastes, this study was undertaken. The main …
Explainable artificial intelligence-assisted virtual screening and bioinformatics approaches for effective bioactivity prediction of phenolic cyclooxygenase-2 (COX-2) …
Abstract Cyclooxygenase-2 (COX-2) inhibitors are nonsteroidal anti-inflammatory drugs that
treat inflammation, pain and fever. This study determined the interaction mechanisms of …
treat inflammation, pain and fever. This study determined the interaction mechanisms of …
[HTML][HTML] A multi-targeted approach to identify potential flavonoids against three targets in the SARS-CoV-2 life cycle
The advent and persistence of the Severe Acute Respiratory Syndrome Coronavirus–2
(SARS-CoV-2)-induced Coronavirus Disease (COVID-19) pandemic since December 2019 …
(SARS-CoV-2)-induced Coronavirus Disease (COVID-19) pandemic since December 2019 …