Unravelling cell migration: defining movement from the cell surface
Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …
Engineering cell–substrate interactions on porous membranes for microphysiological systems
Microphysiological systems are now widely used to recapitulate physiological and
pathological microenvironments in order to study and understand a variety of cellular …
pathological microenvironments in order to study and understand a variety of cellular …
Adhesion strength and contractility enable metastatic cells to become adurotactic
Significant changes in cell stiffness, contractility, and adhesion, ie, mechanotype, are
observed during a variety of biological processes. Whether cell mechanics merely change …
observed during a variety of biological processes. Whether cell mechanics merely change …
[HTML][HTML] Adhesion tunes speed and persistence by coordinating protrusions and extracellular matrix remodeling
Cell migration through 3D environments is essential to development, disease, and
regeneration processes. Conceptual models of migration have been developed primarily on …
regeneration processes. Conceptual models of migration have been developed primarily on …
Positive and negative durotaxis–mechanisms and emerging concepts
Cell migration is controlled by the coordinated action of cell adhesion, cytoskeletal
dynamics, contractility and cell extrinsic cues. Integrins are the main adhesion receptors to …
dynamics, contractility and cell extrinsic cues. Integrins are the main adhesion receptors to …
A novel integrated experimental and computational approach to unravel fibroblast motility in response to chemical gradients in 3D collagen matrices
Fibroblasts play an essential role in tissue repair and regeneration as they migrate to
wounded areas to secrete and remodel the extracellular matrix. Fibroblasts recognize …
wounded areas to secrete and remodel the extracellular matrix. Fibroblasts recognize …
A multiscale whole-cell theory for mechanosensitive migration on viscoelastic substrates
W Shu, CN Kaplan - Biophysical Journal, 2023 - cell.com
Increasing experimental evidence validates that both the elastic stiffness and viscosity of the
extracellular matrix regulate mesenchymal cell behavior, such as the rational switch …
extracellular matrix regulate mesenchymal cell behavior, such as the rational switch …
Optogenetic control of intracellular flows and cell migration: A comprehensive mathematical analysis with a minimal active gel model
The actin cytoskeleton of cells is in continuous motion due to both polymerization of new
filaments and their contraction by myosin II molecular motors. Through adhesion to the …
filaments and their contraction by myosin II molecular motors. Through adhesion to the …
[HTML][HTML] Probing the Protrusions: Lamellipodia and Filopodia in Cancer Invasion and Beyond
L Pratiwi, E Elisa, H Sutanto - Mechanobiology in Medicine, 2024 - Elsevier
The dynamic protrusions of lamellipodia and filopodia have emerged as crucial players in
tumor progression and metastasis. These membrane structures, governed by intricate actin …
tumor progression and metastasis. These membrane structures, governed by intricate actin …
[BOK][B] Assessing Cell Mechanotype as a Prognostic Marker for Metastatic Risk and Recurrence of Cancer
B Yeoman - 2022 - search.proquest.com
The high mortality rate of cancer is associated with metastasis of the primary tumor and can
drastically reduce a patient's 5-year survival rate. Patient outcomes typically scale with the …
drastically reduce a patient's 5-year survival rate. Patient outcomes typically scale with the …