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Carnosine-Niosomal Delivery System for Targeted Cancer Therapy
A Atta, MM Salem, A Reda, TM Mohamed - Cell Biochemistry and …, 2024 - Springer
Cancer is considered to be among the main causes of death worldwide. Treatment options
for cancer are numerous. The type of cancer and its stage of progression determine which …
for cancer are numerous. The type of cancer and its stage of progression determine which …
Unravelling the potential of l-carnosine analog-based nano-assemblies as pH-responsive therapeutics in treating glioma: an in vitro perspective
N Aggarwal, G Singh, HS Panda… - Journal of Materials …, 2024 - pubs.rsc.org
Self-assembled small peptide-based nanoparticles (NPs) constitute a major section of the
biomimetic smart NPs owing to their excellent compatibility and minimal adverse effects in …
biomimetic smart NPs owing to their excellent compatibility and minimal adverse effects in …
Site-specific drug delivery: Molecular insights into the pH-dependent dissociation of carbon dot-carnosine peptide conjugates via DFT studies
D Perera, MS Kandanapitiye, MRR Kooh… - Journal of Molecular …, 2025 - Elsevier
This study employs density functional theory (DFT) simulations to investigate the molecular
structure and dissociation mechanism of a carbon dot (CD)-conjugated anticancer carnosine …
structure and dissociation mechanism of a carbon dot (CD)-conjugated anticancer carnosine …
Dipeptides in CSF and plasma: diagnostic and therapeutic potential in neurological diseases
K Küper, G Poschet, J Rossmann, SF Garbade… - Amino Acids, 2025 - Springer
Dipeptides (DPs), composed of two amino acids (AAs), hold significant therapeutic potential
but remain underexplored. Given the crucial role of AAs in central nervous system (CNS) …
but remain underexplored. Given the crucial role of AAs in central nervous system (CNS) …
Development and in vitro characterization of new carnosine-loaded liposomal formulations
S Russo, A Privitera, G Greco, L Di Pietro… - Journal of Liposome …, 2024 - Taylor & Francis
Carnosine is an endogenous dipeptide characterized by a multimodal mechanism of action.
However, its clinical potential is limited by serum and cytosolic carnosinases, which …
However, its clinical potential is limited by serum and cytosolic carnosinases, which …
Deciphering angiotensin converting enzyme 2 (ACE2) inhibition dynamics: Carnosine's modulatory role in breast cancer proliferation–A clinical sciences perspective
Background Angiotensin-converting enzyme 2 (ACE2) is a pivotal molecular nexus linking
novel coronavirus disease to breast cancer. In-silico investigations have repurposed …
novel coronavirus disease to breast cancer. In-silico investigations have repurposed …
Antioxidant Effect of Carnosine and Carnosine Dinitrosyl Iron Complexes under the Conditions Modeling Peroxidation of Biomolecules
EI Nasybullina, OV Kosmachevskaya… - Applied Biochemistry …, 2024 - Springer
The antioxidant activity of carnosine and of carnosine dinitrosyl iron complexes (DNICs) was
studied. A system with metmyoglobin (metMb) or hemin in combination with tert-butyl …
studied. A system with metmyoglobin (metMb) or hemin in combination with tert-butyl …
Unlocking Precision Diagnostics: A Multimodal Framework Integrating Metabolomics with Advanced Machine Learning Techniques
P Shahnazari, K Kavousi, HR Khorram Khorshid… - bioRxiv, 2025 - biorxiv.org
Integrating multiple omics modalities is a crucial strategy in cancer research, particularly in
metabolomics, enabling early detection and detailed exploration of cancer biomarker …
metabolomics, enabling early detection and detailed exploration of cancer biomarker …
Deconvolution of cancer methylation patterns determines that altered methylation in cancer is dominated by a non-disease associated proliferation signal
H Lalchungnunga, H Atasoy, EC Schwalbe, CM Bacon… - bioRxiv, 2024 - biorxiv.org
All cancers are associated with massive reorganisation of cellular epigenetic patterns,
including extensive changes in the genomic patterns of DNA methylation. However, the …
including extensive changes in the genomic patterns of DNA methylation. However, the …