The protein folding problem
The “protein folding problem” consists of three closely related puzzles:(a) What is the folding
code?(b) What is the folding mechanism?(c) Can we predict the native structure of a protein …
code?(b) What is the folding mechanism?(c) Can we predict the native structure of a protein …
Biological effects of the hypomagnetic field: An analytical review of experiments and theories
During interplanetary flights in the near future, a human organism will be exposed to
prolonged periods of a hypomagnetic field that is 10,000 times weaker than that of Earth's …
prolonged periods of a hypomagnetic field that is 10,000 times weaker than that of Earth's …
On the chemistry of aqueous ammonium acetate droplets during native electrospray ionization mass spectrometry
Ammonium acetate (NH4Ac) is a widely used solvent additive in native electrospray
ionization (ESI) mass spectrometry. NH4Ac can undergo proton transfer to form ammonia …
ionization (ESI) mass spectrometry. NH4Ac can undergo proton transfer to form ammonia …
Physical limits of cells and proteomes
What are the physical limits to cell behavior? Often, the physical limitations can be
dominated by the proteome, the cell's complement of proteins. We combine known protein …
dominated by the proteome, the cell's complement of proteins. We combine known protein …
Relation of completeness of reporting of health research to journals' endorsement of reporting guidelines: systematic review
Objective To assess whether the completeness of reporting of health research is related to
journals' endorsement of reporting guidelines. Design Systematic review. Data sources …
journals' endorsement of reporting guidelines. Design Systematic review. Data sources …
Predicting absolute protein folding stability using generative models
While there has been substantial progress in our ability to predict changes in protein stability
due to amino acid substitutions, progress has been slower in methods to predict the …
due to amino acid substitutions, progress has been slower in methods to predict the …
Protein stability, flexibility and function
Proteins rely on flexibility to respond to environmental changes, ligand binding and chemical
modifications. Potentially, a perturbation that changes the flexibility of a protein may interfere …
modifications. Potentially, a perturbation that changes the flexibility of a protein may interfere …
The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability
SR Hanson, EK Culyba, TL Hsu… - Proceedings of the …, 2009 - National Acad Sciences
The folding energetics of the mono-N-glycosylated adhesion domain of the human immune
cell receptor cluster of differentiation 2 (hCD2ad) were studied systematically to understand …
cell receptor cluster of differentiation 2 (hCD2ad) were studied systematically to understand …
Biophysical and mechanistic models for disease-causing protein variants
The rapid decrease in DNA sequencing cost is revolutionizing medicine and science. In
medicine, genome sequencing has revealed millions of missense variants that change …
medicine, genome sequencing has revealed millions of missense variants that change …
Computational tools help improve protein stability but with a solubility tradeoff
Accurately predicting changes in protein stability upon amino acid substitution is a much
sought after goal. Destabilizing mutations are often implicated in disease, whereas …
sought after goal. Destabilizing mutations are often implicated in disease, whereas …