Sphingolipids and phospholipids in insulin resistance and related metabolic disorders
Obesity, insulin resistance, type 2 diabetes mellitus and cardiovascular disease form a
metabolic disease continuum that has seen a dramatic increase in prevalence in developed …
metabolic disease continuum that has seen a dramatic increase in prevalence in developed …
Retinoid pathway and cancer therapeutics
N Bushue, YJY Wan - Advanced drug delivery reviews, 2010 - Elsevier
The retinoids are a class of compounds that are structurally related to vitamin A. Retinoic
acid, which is the active metabolite of retinol, regulates a wide range of biological processes …
acid, which is the active metabolite of retinol, regulates a wide range of biological processes …
Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer
Cell state transitions control the functional behavior of cancer cells. Epithelial-to-
mesenchymal transition (EMT) confers cancer stem cell-like properties, enhanced …
mesenchymal transition (EMT) confers cancer stem cell-like properties, enhanced …
Targeting breast cancer stem cells through retinoids: a new hope for treatment
Breast cancer is a complex and diverse disease accounting for nearly 30% of all cancers
diagnosed in females. But unfortunately, patients develop resistance to the existing …
diagnosed in females. But unfortunately, patients develop resistance to the existing …
[HTML][HTML] Association of FABP5 expression with poor survival in triple-negative breast cancer: implication for retinoic acid therapy
RZ Liu, K Graham, DD Glubrecht, DR Germain… - The American journal of …, 2011 - Elsevier
Recent studies using animal models suggest that expression of FABP5 drives the
stimulation of cell growth observed in estrogen receptor (ER)-negative breast cancer cells …
stimulation of cell growth observed in estrogen receptor (ER)-negative breast cancer cells …
Minireview: nuclear receptors and breast cancer
SD Conzen - Molecular endocrinology, 2008 - academic.oup.com
Until recently, the study of nuclear receptor (NR) function in breast cancer biology has been
largely limited to estrogen and progesterone receptors. The development of reliable gene …
largely limited to estrogen and progesterone receptors. The development of reliable gene …
Retinol binding protein 4 antagonists and protein synthesis inhibitors: Potential for therapeutic development
N Kim, R Priefer - European Journal of Medicinal Chemistry, 2021 - Elsevier
Abstract Retinol-binding protein 4 (RBP4) is a serum protein that transports Vitamin A. RBP4
is correlated with numerous diseases and metabolic syndromes, including insulin resistance …
is correlated with numerous diseases and metabolic syndromes, including insulin resistance …
Retinoids and their biological effects against cancer
F Alizadeh, A Bolhassani, A Khavari, SZ Bathaie… - International …, 2014 - Elsevier
There are more than 4000 natural and synthetic molecules structurally and/or functionally
related to vitamin A. Retinoids are a class of these compounds that are structurally …
related to vitamin A. Retinoids are a class of these compounds that are structurally …
Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis
The synthetic retinoid Fenretinide (FEN) increases insulin sensitivity in obese rodents and is
in early clinical trials for treatment of insulin resistance in obese humans with hepatic …
in early clinical trials for treatment of insulin resistance in obese humans with hepatic …
Metabolism and bioavailability of flavonoids in chemoprevention: current analytical strategies and future prospectus
JK Prasain, S Barnes - Molecular pharmaceutics, 2007 - ACS Publications
Flavonoids are structurally diverse and among the most ubiquitous groups of dietary
polyphenols distributed in various fruits and vegetables. Many have been proposed to be …
polyphenols distributed in various fruits and vegetables. Many have been proposed to be …