In all eukaryotes, the target of rapamycin (TOR) signalling pathway couples energy and
nutrient abundance to the execution of cell growth and division, owing to the ability of TOR …

Cellular lipid metabolism and homeostasis are controlled by sterol regulatory-element
binding proteins (SREBPs). In addition to performing canonical functions in the …

B. DNA binding properties C. PPAR ligand-binding properties D. Alternative pathways for
PPAR activation E. PPAR-mediated transactivation properties III. Physiological Aspects A …

Improved knowledge of all aspects of adipose biology will be required to counter the
burgeoning epidemic of obesity. Interest in adipogenesis has increased markedly over the …

Obesity is defined medically as a state of increased body weight, more specifically adipose
tissue, of sufficient magnitude to produce adverse health consequences. There has been an …

Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Obesity and its associated comorbidities are among the most prevalent and challenging
conditions confronting the medical profession in the 21st century. A major metabolic …

The past twenty years have seen great strides in our understanding of the molecular
regulation of differentiation for a whole host of specific cell types. The development of …

A detailed understanding of the processes governing adipose tissue formation will be
instrumental in combating the obesity epidemic. Much progress has been made in the last …

Adipogenesis is the process by which precursor stem cells differentiate into lipid laden
adipocytes. Adipogenesis is regulated by a complex and highly orchestrated gene …