Melatonin and cancer hallmarks

WH Talib - Molecules, 2018 - mdpi.com
Melatonin is a natural indoleamine produced by the pineal gland that has many functions,
including regulation of the circadian rhythm. Many studies have reported the anticancer …

Endocrine disrupting chemicals in polycystic ovary syndrome: the relevant role of the theca and granulosa cells in the pathogenesis of the ovarian dysfunction

M Jozkowiak, H Piotrowska-Kempisty, D Kobylarek… - Cells, 2022 - mdpi.com
Polycystic ovary syndrome (PCOS) is the most common heterogeneous endocrine disorder
among women of reproductive age. The pathogenesis of PCOS remains elusive; however …

Exploring the mechanical perspective of a new anti-tumor agent: melatonin

S Rohilla, M Singh, S Priya, WH Almalki… - Journal of …, 2023 - dl.begellhouse.com
Melatonin is a serotonin-derived pineal gland hormone with many biological functions like
regulating the sleep-wake cycle, circadian rhythm, menstrual cycle, aging, immunity, and …

Understanding the mechanism of action of melatonin, which induces ROS production in cancer cells

J Florido, C Rodriguez-Santana, L Martinez-Ruiz… - Antioxidants, 2022 - mdpi.com
Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have
evolved as regulators of important signaling pathways. In this context, tumor cells have an …

Melatonin inhibiting the survival of human gastric cancer cells under ER stress involving autophagy and Ras‐Raf‐MAPK signalling

Y Huang, K Yuan, M Tang, J Yue, L Bao… - Journal of cellular …, 2021 - Wiley Online Library
Melatonin exhibits antitumour activities in the treatment of many human cancers. In the
present study, we aimed to improve the therapeutic potential of melatonin in gastric cancer …

Ginsenoside Rg5 induces G2/M phase arrest, apoptosis and autophagy via regulating ROS-mediated MAPK pathways against human gastric cancer

Y Liu, D Fan - Biochemical pharmacology, 2019 - Elsevier
Ginsenoside Rg5, a rare saponin belonging to the family of protopanaxadiol ginsenosides,
has been demonstrated to have potential anti-tumor effects in various cancers. However, the …

Mechanisms underlying tumor suppressive properties of melatonin

SC Bondy, A Campbell - International journal of molecular sciences, 2018 - mdpi.com
There is considerable evidence that melatonin may be of use in the prevention and
treatment of cancer. This manuscript will review some of the human, animal and cellular …

[HTML][HTML] The role of melatonin in polycystic ovary syndrome: A review

S Mojaverrostami, N Asghari… - International journal …, 2019 - ncbi.nlm.nih.gov
Background Polycystic ovary syndrome (PCOS) is a widespread endocrine disorder,
affecting approximately 20% of women within reproductive age. It is associated with …

The role of melatonin on chemotherapy-induced reproductive toxicity

H Haghi-Aminjan, MH Asghari… - Journal of Pharmacy …, 2018 - academic.oup.com
Objectives Reproductive malfunctions after chemotherapy still are a reason of reducing
fertility and need specialized intensive care. The aim of this review was to investigate the …

The emergence of melatonin in oncology: Focus on colorectal cancer

E Gil‐Martín, J Egea, RJ Reiter… - Medicinal research …, 2019 - Wiley Online Library
Within the last few decades, melatonin has increasingly emerged in clinical oncology as a
naturally occurring bioactive molecule with substantial anticancer properties and a …