From basics to clinical: a comprehensive review on spinal cord injury

NA Silva, N Sousa, RL Reis, AJ Salgado - Progress in neurobiology, 2014 - Elsevier
Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

Characterizing natural recovery after traumatic spinal cord injury

S Kirshblum, B Snider, F Eren, J Guest - Journal of neurotrauma, 2021 - liebertpub.com
The predominant tool used to predict outcomes after traumatic spinal cord injury (SCI) is the
International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI), in …

Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power …

JW Fawcett, A Curt, JD Steeves, WP Coleman… - Spinal cord, 2007 - nature.com
Abstract The International Campaign for Cures of Spinal Cord Injury Paralysis (ICCP)
supported an international panel tasked with reviewing the methodology for clinical trials in …

[HTML][HTML] Antioxidant therapies in traumatic brain and spinal cord injury

M Bains, ED Hall - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2012 - Elsevier
Free radical formation and oxidative damage have been extensively investigated and
validated as important contributors to the pathophysiology of acute central nervous system …

Corticospinal-motor neuronal plasticity promotes exercise-mediated recovery in humans with spinal cord injury

HJ Jo, MA Perez - Brain, 2020 - academic.oup.com
Rehabilitative exercise in humans with spinal cord injury aims to engage residual neural
networks to improve functional recovery. We hypothesized that exercise combined with non …

Autologous olfactory ensheathing cell transplantation in human paraplegia: a 3-year clinical trial

A Mackay-Sim, F Feron, J Cochrane… - Brain, 2008 - academic.oup.com
Olfactory ensheathing cells show promise in preclinical animal models as a cell
transplantation therapy for repair of the injured spinal cord. This is a report of a clinical trial of …

A clinical prediction rule for ambulation outcomes after traumatic spinal cord injury: a longitudinal cohort study

JJ van Middendorp, AJF Hosman, ART Donders… - The Lancet, 2011 - thelancet.com
Background Traumatic spinal cord injury is a serious disorder in which early prediction of
ambulation is important to counsel patients and to plan rehabilitation. We developed a …

Efficacy of virtual reality rehabilitation after spinal cord injury: a systematic review

AVL De Araújo, JFO Neiva… - BioMed research …, 2019 - Wiley Online Library
Background. Spinal cord injury (SCI) is often associated with long‐term impairments related
to functional limitations in the sensorimotor system. The use of virtual reality (VR) technology …

Cell therapies for spinal cord injury: a review of the clinical trials and cell-type therapeutic potential

BF Ribeiro, BC da Cruz, BM de Sousa, PD Correia… - Brain, 2023 - academic.oup.com
Spinal cord injury (SCI) is an as yet untreatable neuropathology that causes severe
dysfunction and disability. Cell-based therapies hold neuroregenerative and neuroprotective …

Axon growth inhibition by RhoA/ROCK in the central nervous system

Y Fujita, T Yamashita - Frontiers in neuroscience, 2014 - frontiersin.org
Rho kinase (ROCK) is a serine/threonine kinase and a downstream target of the small
GTPase Rho. The RhoA/ROCK pathway is associated with various neuronal functions such …