Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer

Z Weng, B Zhang, C Wu, F Yu, B Han, B Li… - Journal of hematology & …, 2021 - Springer
Extracellular vesicles (EVs) are cell-derived membrane structures enclosing proteins, lipids,
RNAs, metabolites, growth factors, and cytokines. EVs have emerged as essential …

The emerging role of exosomes in innate immunity, diagnosis and therapy

P Gangadaran, H Madhyastha, R Madhyastha… - Frontiers in …, 2023 - frontiersin.org
Exosomes, which are nano-sized transport bio-vehicles, play a pivotal role in maintaining
homeostasis by exchanging genetic or metabolic information between different cells …

[HTML][HTML] Radioiodine therapy in advanced differentiated thyroid cancer: resistance and overcoming strategy

Y Liu, J Wang, X Hu, Z Pan, T Xu, J Xu, L Jiang… - Drug Resistance …, 2023 - Elsevier
Thyroid cancer is the most prevalent endocrine tumor and its incidence is fast-growing
worldwide in recent years. Differentiated thyroid cancer (DTC) is the most common …

Advances and clinical challenges of mesenchymal stem cell therapy

R Mei, Z Wan, C Yang, X Shen, R Wang… - Frontiers in …, 2024 - frontiersin.org
In recent years, cell therapy has provided desirable properties for promising new drugs.
Mesenchymal stem cells are promising candidates for develo** genetic engineering and …

Improving outcomes of tyrosine kinase inhibitors in hepatocellular carcinoma: new data and ongoing trials

L Mou, X Tian, B Zhou, Y Zhan, J Chen, Y Lu… - Frontiers in …, 2021 - frontiersin.org
Targeted therapies such as oral tyrosine kinase inhibitors (TKIs) are the main therapeutic
strategy effective for advanced hepatocellular carcinoma (HCC). Currently six tyrosine …

Mesenchymal stem cell-derived extracellular vesicles in Cancer Therapy Resistance: from Biology to Clinical Opportunity

C Shan, Y Liang, K Wang, P Li - International Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) are a type of stromal cells characterized by their properties
of self-renewal and multi-lineage differentiation, which make them prominent in regenerative …

Bioengineered mesenchymal-stromal-cell-derived extracellular vesicles as an improved drug delivery system: methods and applications

C Ulpiano, CL da Silva, GA Monteiro - Biomedicines, 2023 - mdpi.com
Extracellular vesicles (EVs) are cell-derived nano-sized lipid membranous structures that
modulate cell–cell communication by transporting a variety of biologically active cellular …

Customizing cancer treatment at the nanoscale: A focus on anaplastic thyroid cancer therapy

J Wang, J Tan, B Wu, R Wu, Y Han, C Wang… - Journal of …, 2023 - Springer
Anaplastic thyroid cancer (ATC) is a rare but highly aggressive kind of thyroid cancer.
Various therapeutic methods have been considered for the treatment of ATC, but its …

Cellular organelles as drug carriers for disease treatment

J Hu, Y Liu, Y Du, X Peng, Z Liu - Journal of Controlled Release, 2023 - Elsevier
Organelles not only constitute the basic structure of the cell but also are important in
maintaining the normal physiological activities of the cell. With the development of …

Identification of angiogenic cargo in extracellular vesicles secreted from human adipose tissue-derived stem cells and induction of angiogenesis in vitro and in vivo

P Gangadaran, RL Rajendran, JM Oh, EJ Oh… - Pharmaceutics, 2021 - mdpi.com
Angiogenesis is defined as the generation of new blood vessels or the sprouting of
endothelial cells from a pre-existing vascular network. Angiogenesis occurs during the …