Chromosome segregation during cell division requires a bipolar mitotic spindle. Therefore,
how the spindle is formed, maintained, and functions is of fundamental importance for all …

Mitotic spindles are self-organizing protein machines that harness teams of multiple force
generators to drive chromosome segregation. Kinesins are key members of these force …

Cytoplasmic dynein is an approximately 1.4 MDa multi‐protein complex that transports many
cellular cargoes towards the minus ends of microtubules. Several in vitro studies of …

To mediate the degradation of biomacromolecules, lysosomes must traffic towards cargo-
carrying vesicles for subsequent membrane fusion or fission. Mutations of the lysosomal …

Kinesins are a diverse superfamily of microtubule-based motors that perform fundamental
roles in intracellular transport, cytoskeletal dynamics and cell division. These motors share a …

Molecular motors usually work together in teams within the cell. However, studying
coordination among these nanomachines has posed a challenge. Here, we used …

Kinesins are essential for the transport and positioning of several biomolecules through
moving along the microtubule in eukaryotic cells. Up to now, there are 14 kinesin family …

During cell division, mitotic motors organize microtubules in the bipolar spindle into either
polar arrays at the spindle poles or a" nematic" network of aligned microtubules at the …

Mitosis is the process by which eukaryotic cells organize and segregate their chromosomes
in preparation for cell division. It is accomplished by a cellular machine composed largely of …

Cytoskeletal remodeling is essential to eukaryotic cell division and morphogenesis. The
mechanical forces driving the restructuring are attributed to the action of molecular motors …