What is the surgical benefit of utilizing 5-aminolevulinic acid for fluorescence-guided surgery of malignant gliomas?
The current neurosurgical goal for patients with malignant gliomas is maximal safe resection
of the contrast-enhancing tumor. However, a complete resection of the contrast-enhancing …
of the contrast-enhancing tumor. However, a complete resection of the contrast-enhancing …
Fluorescence-guided surgery: a review on timing and use in brain tumor surgery
Fluorescence-guided surgery (FGS) allows surgeons to have improved visualization of
tumor tissue in the operating room, enabling maximal safe resection of malignant brain …
tumor tissue in the operating room, enabling maximal safe resection of malignant brain …
Localization of protoporphyrin IX during glioma-resection surgery via paired stimulated Raman histology and fluorescence microscopy
The most widely used fluorophore in glioma-resection surgery, 5-aminolevulinic acid (5-
ALA), is thought to cause the selective accumulation of fluorescent protoporphyrin IX (PpIX) …
ALA), is thought to cause the selective accumulation of fluorescent protoporphyrin IX (PpIX) …
5-Aminolevulinic acid-derived tumor fluorescence: the diagnostic accuracy of visible fluorescence qualities as corroborated by spectrometry and histology and …
W Stummer, JC Tonn, C Goetz, W Ullrich, H Stepp… - …, 2014 - journals.lww.com
BACKGROUND: 5-Aminolevulinic acid is used for fluorescence-guided resections. During
resection, different macroscopic fluorescence qualities (“strong,”“weak”) can be …
resection, different macroscopic fluorescence qualities (“strong,”“weak”) can be …
Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker
Object Accurate discrimination between tumor and normal tissue is crucial for optimal tumor
resection. Qualitative fluorescence of protoporphyrin IX (PpIX), synthesized endogenously …
resection. Qualitative fluorescence of protoporphyrin IX (PpIX), synthesized endogenously …
Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery
OBJECT Previous studies in high-grade gliomas (HGGs) have indicated that protoporphyrin
IX (PpIX) accumulates in higher concentrations in tumor tissue, and, when used to guide …
IX (PpIX) accumulates in higher concentrations in tumor tissue, and, when used to guide …
Photonanomedicine: a convergence of photodynamic therapy and nanotechnology
As clinical nanomedicine has emerged over the past two decades, phototherapeutic
advancements using nanotechnology have also evolved and impacted disease …
advancements using nanotechnology have also evolved and impacted disease …
Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas
Object Greater extent of resection (EOR) for patients with low-grade glioma (LGG)
corresponds with improved clinical outcome, yet remains a central challenge to the …
corresponds with improved clinical outcome, yet remains a central challenge to the …
[HTML][HTML] First-in-human study of PET and optical dual-modality image-guided surgery in glioblastoma using 68Ga-IRDye800CW-BBN
Purpose: Despite the use of fluorescence-guided surgery (FGS), maximum safe resection of
glioblastoma multiforme (GBM) remains a major challenge. It has restricted surgeons …
glioblastoma multiforme (GBM) remains a major challenge. It has restricted surgeons …
Intraoperative fluorescence imaging for personalized brain tumor resection: current state and future directions
Introduction Fluorescence-guided surgery is one of the rapidly emerging methods of surgical
“theranostics.” In this review, we summarize current fluorescence techniques used in …
“theranostics.” In this review, we summarize current fluorescence techniques used in …