Organoids are 3D cell culture systems that mimic some of the structural and functional
characteristics of an organ. Organoid cultures provide the opportunity to study organ-level …

The development, maintenance of healthy bone and regeneration of injured tissue in the
human body comprise a set of intricate and finely coordinated processes. However, an …

Stem cells respond to nanoscale surface features, with changes in cell growth and
differentiation mediated by alterations in cell adhesion. The interaction of nanotopographical …

Growing interest in exploring mechanically mediated biological phenomena has resulted in
cell culture substrates and 3D matrices with variable stiffnesses becoming standard tools in …

Hydrogels mimic many of the physical properties of soft tissue and are widely used
biomaterials for tissue engineering and regenerative medicine. Synthetic hydrogels have …

The field of stem cells and regenerative medicine offers considerable promise as a means of
delivering new treatments for a wide range of diseases. In order to maximize the …

Stem cell behaviors are regulated by multiple microenvironmental cues. As an external
signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate …

The use of mesenchymal stem cells (MSCs) for clinical purposes has skyrocketed in the past
decade. Their multilineage differentiation potentials and immunomodulatory properties have …

Enabling angiogenesis is critical for the success of tissue repair therapies and the fate of
tissue-engineered constructs. Although many biochemical signaling molecules have been …

Advances in nanotechnology provided the basis for fabrication of nanoparticulate delivery
systems with large ratios of surface area to volume, rendering them very effective within the …