Next-generation sequencing and triple-negative breast cancer: insights and applications

D Tierno, G Grassi, S Scomersi, M Bortul… - International Journal of …, 2023 - mdpi.com
The poor survival of triple-negative breast cancer (TNBC) is due to its aggressive behavior,
large heterogeneity, and high risk of recurrence. A comprehensive molecular investigation of …

Understanding and harnessing triple-negative breast cancer-related microbiota in oncology

C Devoy, Y Flores Bueso, M Tangney - Frontiers in Oncology, 2022 - frontiersin.org
Bacterial inhabitants of the body have the potential to play a role in various stages of cancer
initiation, progression, and treatment. These bacteria may be distal to the primary tumour …

Breast cancer in adolescents and young adults less than 40 years of age in Nigeria: A retrospective analysis

A Ntekim, M Oluwasanu… - International journal of …, 2022 - Wiley Online Library
Background. Breast cancer among adolescents and young adult (AYA) females aged 15‐39
years is associated with different patterns of aggressiveness, as well as psychosocial and …

FGFR2 genetic variants in women with breast cancer

T Dix-Peek, C Dickens… - Molecular …, 2023 - spandidos-publications.com
Black African populations are more genetically diverse than others, but genetic variants
have been studied primarily in European populations. The present study examined the …

[HTML][HTML] Persistent EGFR/K-RAS/SIAH pathway activation drives chemo-resistance and early tumor relapse in triple-negative breast cancer

AH Tang, RA Hoefer, ML Guye… - Cancer Drug Resistance, 2022 - ncbi.nlm.nih.gov
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. It
disproportionately affects BRCA mutation carriers and young women, especially African …

Breast Cancer Phenotypes in Africa: A Sco** Review and Meta-Analysis

AF Onyia, TA Nana, EA Adewale, AO Adebesin… - JCO Global …, 2023 - ascopubs.org
PURPOSE Africans have been associated with more aggressive forms of breast cancer
(BC). However, there is a lack of data regarding the incidence and distribution of different …

Liposomal‐Naringenin Radiosensitizes Triple‐Negative Breast Cancer MDA‐MB‐231 Cells In Vitro

K Pearce, SI Cairncross… - IET nanobiotechnology, 2024 - Wiley Online Library
Background. Naringenin has shown great promise in the realm of cancer therapeutics,
demonstrating excellent cytotoxic action toward cancer cells and the enhanced effects of …

Assessing the continuum of care in Sub-Saharan African hospitals performing surgery for breast cancer: a secondary analysis of the GlobalSurg 3 study

FHR Gnangnon, I Lawani, SR Knight, A Parenté… - BMC cancer, 2024 - Springer
Background While breast cancer incidence rates in Sub-Saharan Africa (SSA) are among
the lowest worldwide, mortality rates remain among the highest, reflecting particularly poor …

Subpopulation treatment effect pattern plot analysis: a prognostic model for distant recurrence-free survival to estimate delayed adjuvant chemotherapy initiation effect …

Z Morante, Y Ferreyra, JA Pinto, N Valdivieso… - Frontiers in …, 2023 - frontiersin.org
Introduction Triple-negative breast cancer (TNBC) is a heterogeneous disease associated
with a poor prognosis. Delaying in time to start adjuvant chemotherapy (TTC) has been …

Potential Therapeutic Targets in Triple‐Negative Breast Cancer Based on Gene Regulatory Network Analysis: A Comprehensive Systems Biology Approach

M Ahmadi, N Barkhoda, A Alizamir… - … Journal of Breast …, 2024 - Wiley Online Library
Background: Triple‐negative breast cancer (TNBC) is an aggressive subtype with limited
treatment options. This study is aimed at identifying potential therapeutic targets in TNBC …