Sildenafil 4.0—Integrated synthetic chemistry, formulation and analytical strategies effecting immense therapeutic and societal impact in the fourth industrial era

A Ouranidis, A Tsiaxerli, E Vardaka, CK Markopoulou… - Pharmaceuticals, 2021 - mdpi.com
Sildenafil is a potent selective, reversible inhibitor of phosphodiesterase type 5 (PDE5)
approved for the treatment of erectile dysfunction and pulmonary arterial hypertension …

HPLC-UV assay of tramadol and O-desmethyltramadol in human plasma containing other drugs potentially co-administered to participants in a paediatric population …

O Yoo, EKY Tang, MN Nguyen, S Salman… - … of Chromatography B, 2021 - Elsevier
Multimodal analgesia is employed in paediatric pain management to maximise analgesia
and minimise side effects. Tramadol is dosed at 1–1.5 mg/kg to treat severe pain in children …

Electrochemical sensor based on CuO/reduced graphene nanoribbons and ionic liquid for simultaneous determination of tramadol, olanzapine and acetaminophen

H Shahinfard, M Shabani-Nooshabadi, A Reisi-Vanani… - Carbon Letters, 2023 - Springer
In the present investigation, a new electrochemical sensor based on carbon paste electrode
was applied to simultaneous determine the tramadol, olanzapine and acetaminophen for the …

Anatase titanium oxide nanoparticles and multi-walled carbon nanotubes-modified carbon paste electrode for simultaneous determination of avanafil and doxorubicin …

AMBH Ali, AH Rageh, FAM Abdel-aal… - Microchemical …, 2023 - Elsevier
Patients who receive anticancer drugs, might experience loss of sexual desire together with
erectile dysfunction as one of cancer medications' adverse effects. This might have a …

A gold nanoparticle-based immunochromatographic assay for simultaneous detection of multiplex sildenafil adulterants in health food by only one antibody

F He, J Yang, T Zou, Z Xu, Y Tian, W Sun, H Wang… - Analytica Chimica …, 2021 - Elsevier
In the last few years, sildenafil and its analogues have emerged as an illegal ingredient in
health food and products, causing illness and death. To address this problem, herein, a gold …

Application of oxidized multi-walled carbon nanotubes and zeolite nanoparticles for simultaneous preconcentration of codeine and tramadol in saliva prior to HPLC …

N Soltani, S Habibollahi, A Salamat - Journal of Chromatography B, 2023 - Elsevier
In this work, a dispersive micro-solid phase extraction technique along with high-
performance liquid chromatography-UV detection was developed for simultaneous …

Simultaneous determination of tramadol and paracetamol in human plasma using LC-MS/MS and application in bioequivalence study of fixed-dose combination

GOK Loh, EYL Wong, CZ Goh, YTF Tan, YL Lee… - Annals of …, 2023 - Taylor & Francis
The study aimed to develop a sensitive and high-throughput liquid chromatography coupled
with tandem mass spectrometry method to quantify concentrations of tramadol and …

Ultrasound-assisted magnetic dispersive micro-solid-phase extraction based on carbon quantum dots/zeolite imidazolate framework-90/polyvinyl pyrrolidone/Fe 3 O 4 …

K Ahmadi, A Abolfathi, S Nasirimoghadam… - RSC …, 2024 - pubs.rsc.org
A four-part and sustainable nanocomposite composed of carbon quantum dots modified with
zeolite imidazolate framework-90, polyvinyl pyrrolidone and magnetite (CQDs/ZIF …

Nanoporous Ethylenediamine-Functionalized Metal–Organic Framework MIL-101 for the Removal of Proteins and Antipsychotic Drugs from Serum Samples

Z Zhang, W Han, T Lou, L Ma, W Zhou… - ACS Applied Nano …, 2022 - ACS Publications
The development of functional materials for efficient protein removal and antipsychotic drug
extraction in biological samples is attracting great interest. In this study, a nanoscale …

[HTML][HTML] Platelet Membrane-Encapsulated Poly (lactic-co-glycolic acid) Nanoparticles Loaded with Sildenafil for Targeted Therapy of Vein Graft Intimal Hyperplasia

F Yang, Y Qiu, X **e, X Zhou, S Wang, J Weng… - International Journal of …, 2024 - Elsevier
Autologous vein grafts have attracted widespread attention for their high transplantation
success rate and low risk of immune rejection. However, this technique is limited by the …