Alternative animal models of aging research
S Holtze, E Gorshkova, S Braude… - Frontiers in Molecular …, 2021 - frontiersin.org
Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …
From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology
African annual fishes from the genus Nothobranchius are small teleosts that inhabit
temporary water bodies subject to annual desiccation due to the alternation of the monsoon …
temporary water bodies subject to annual desiccation due to the alternation of the monsoon …
Insights into sex chromosome evolution and aging from the genome of a short-lived fish
The killifish Nothobranchius furzeri is the shortest-lived vertebrate that can be bred in the
laboratory. Its rapid growth, early sexual maturation, fast aging, and arrested embryonic …
laboratory. Its rapid growth, early sexual maturation, fast aging, and arrested embryonic …
Non-model model organisms
Abstract Model organisms are widely used in research as accessible and convenient
systems to study a particular area or question in biology. Traditionally only a handful of …
systems to study a particular area or question in biology. Traditionally only a handful of …
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation
E Kelmer Sacramento, JM Kirkpatrick… - Molecular systems …, 2020 - embopress.org
A progressive loss of protein homeostasis is characteristic of aging and a driver of
neurodegeneration. To investigate this process quantitatively, we characterized proteome …
neurodegeneration. To investigate this process quantitatively, we characterized proteome …
[HTML][HTML] A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate
Aging is a complex process that affects multiple organs. Modeling aging and age-related
diseases in the lab is challenging because classical vertebrate models have relatively long …
diseases in the lab is challenging because classical vertebrate models have relatively long …
The African turquoise killifish: A research organism to study vertebrate aging and diapause
The African turquoise killifish has recently gained significant traction as a new research
organism in the aging field. Our understanding of aging has strongly benefited from …
organism in the aging field. Our understanding of aging has strongly benefited from …
From humans to hydra: patterns of cancer across the tree of life
TAF Albuquerque, L Drummond do Val… - Biological …, 2018 - Wiley Online Library
Cancer is a disease of multicellularity; it originates when cells become dysregulated due to
mutations and grow out of control, invading other tissues and provoking discomfort …
mutations and grow out of control, invading other tissues and provoking discomfort …
RNA‐seq of the aging brain in the short‐lived fish N. furzeri – conserved pathways and novel genes associated with neurogenesis
The brains of teleost fish show extensive adult neurogenesis and neuronal regeneration.
The patterns of gene regulation during fish brain aging are unknown. The short‐lived teleost …
The patterns of gene regulation during fish brain aging are unknown. The short‐lived teleost …
Laboratory breeding of the short-lived annual killifish Nothobranchius furzeri
Turquoise killifish, Nothobranchius furzeri, have an intrinsically short life span, with a median
life span of< 6 months and a maximum (90%) life span of 9 months. This short life span …
life span of< 6 months and a maximum (90%) life span of 9 months. This short life span …