In epithelial cancers, cells must invade through basement membranes (BMs) to metastasize.
The BM, a thin layer of extracellular matrix underlying epithelial and endothelial tissues, is …

In a forest of a hundred thousand trees, no two leaves are alike. Similarly, no two cells in a
genetically identical group are the same. This heterogeneity at the single-cell level has been …

Cell size varies greatly between cell types, yet within a specific cell type and growth
condition, cell size is narrowly distributed. Why maintenance of a cell-type specific cell size …

Cell size is tightly controlled in healthy tissues, but it is unclear how deviations in cell size
affect cell physiology. To address this, we measured how the cell's proteome changes with …

Yes-associated protein (YAP) is a transcriptional co-activator that regulates cell proliferation
and survival by binding to a select set of enhancers for target gene activation. How YAP …

Cellular growth is the result of passive physical constraints and active biological processes.
Their interplay leads to the appearance of robust and ubiquitous scaling laws relating …

When animal cells enter mitosis, they round up to become spherical. This shape change is
accompanied by changes in mechanical properties. Multiple studies using different …

Life emerges from thousands of biochemical processes occurring within a shared
intracellular environment. We have gained deep insights from in vitro reconstitution of …

Despite decades of research, how mammalian cell size is controlled remains unclear
because of the difficulty of directly measuring growth at the single-cell level. Here we report …

To achieve a stable size distribution over multiple generations, proliferating cells require a
means of counteracting stochastic noise in the rate of growth, the time spent in various …