Endosomes, lysosomes and lysosome-related organelles are emerging as important Ca2+
storage cellular compartments with a central role in intracellular Ca2+ signalling …

At a given cytosolic domain of a chromaffin cell, the rate and amplitude of the Ca2+
concentration ([Ca2+] c) depends on at least four efficient regulatory systems: 1) …

Changes in cytosolic calcium concentration are crucial for a variety of cellular processes in
all cells. It has long been appreciated that calcium is stored and released from intracellular …

The interior lumen of acidic organelles (eg, endosomes, secretory granules, lysosomes and
plant vacuoles) is an important platform for modification, transport and degradation of …

A paroxysmal depolarization shift (PDS) has been suggested to be a hallmark for epileptic
activity in partial-onset seizures. By monitoring membrane potentials and currents in pairs of …

Catestatin is a 21-amino acid residue, cationic and hydrophobic peptide that is formed
endogenously by proteolytic cleavage of its precursor chromogranin A, a major protein co …

Katz and co-workers showed that Ca2+ triggers exocytosis. The existence of sub-micrometer
domains of greater than 100μM [Ca2+] i was postulated on theoretical grounds. Using a …

Chromogranin A (CgA) is a prohormone and granulogenic factor in neuroendocrine tissues
with a regulated secretory pathway. The impact of CgA depletion on secretory granule …

An increase in the concentration of cytosolic free Ca 2+ is a key component regulating
different cellular processes ranging from egg fertilization, active secretion and movement, to …

Endolysosomes are emerging as key players that generate as well as respond to
intracellular Ca 2+ signals. The role of Ca 2+ in modulating acidic organelle function has …