Current challenges and future opportunities of phage therapy
Antibiotic resistance is a major public health challenge worldwide, whose implications for
global health might be devastating if novel antibacterial strategies are not quickly …
global health might be devastating if novel antibacterial strategies are not quickly …
Bacteriophage host range and bacterial resistance
Host range describes the breadth of organisms a parasite is capable of infecting, with limits
on host range stemming from parasite, host, or environmental characteristics. Parasites can …
on host range stemming from parasite, host, or environmental characteristics. Parasites can …
Bacteria deplete deoxynucleotides to defend against bacteriophage infection
DNA viruses and retroviruses consume large quantities of deoxynucleotides (dNTPs) when
replicating. The human antiviral factor SAMHD1 takes advantage of this vulnerability in the …
replicating. The human antiviral factor SAMHD1 takes advantage of this vulnerability in the …
Experimental infection of domestic dogs and cats with SARS-CoV-2: Pathogenesis, transmission, and response to reexposure in cats
AM Bosco-Lauth, AE Hartwig… - Proceedings of the …, 2020 - National Acad Sciences
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has reached nearly every country in the world with extraordinary person-to-person …
has reached nearly every country in the world with extraordinary person-to-person …
Prokaryotic viperins produce diverse antiviral molecules
Viperin is an interferon-induced cellular protein that is conserved in animals. It has
previously been shown to inhibit the replication of multiple viruses by producing the …
previously been shown to inhibit the replication of multiple viruses by producing the …
Bacterial retrons encode phage-defending tripartite toxin–antitoxin systems
Retrons are prokaryotic genetic retroelements encoding a reverse transcriptase that
produces multi-copy single-stranded DNA (msDNA). Despite decades of research on the …
produces multi-copy single-stranded DNA (msDNA). Despite decades of research on the …
[HTML][HTML] Bacterial retrons function in anti-phage defense
Retrons are bacterial genetic elements comprised of a reverse transcriptase (RT) and a non-
coding RNA (ncRNA). The RT uses the ncRNA as template, generating a chimeric …
coding RNA (ncRNA). The RT uses the ncRNA as template, generating a chimeric …
Lessons learned from the first 10 consecutive cases of intravenous bacteriophage therapy to treat multidrug-resistant bacterial infections at a single center in the …
Background Due to increasing multidrug-resistant (MDR) infections, there is an interest in
assessing the use of bacteriophage therapy (BT) as an antibiotic alternative. After the first …
assessing the use of bacteriophage therapy (BT) as an antibiotic alternative. After the first …
An E1–E2 fusion protein primes antiviral immune signalling in bacteria
In all organisms, innate immune pathways sense infection and rapidly activate potent
immune responses while avoiding inappropriate activation (autoimmunity). In humans, the …
immune responses while avoiding inappropriate activation (autoimmunity). In humans, the …
Systematic exploration of Escherichia coli phage–host interactions with the BASEL phage collection
Bacteriophages, the viruses infecting bacteria, hold great potential for the treatment of
multidrug-resistant bacterial infections and other applications due to their unparalleled …
multidrug-resistant bacterial infections and other applications due to their unparalleled …