The amyloid cascade hypothesis: an updated critical review
Results from recent clinical trials of antibodies that target amyloid-β (Aβ) for Alzheimer's
disease have created excitement and have been heralded as corroboration of the amyloid …
disease have created excitement and have been heralded as corroboration of the amyloid …
Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight
Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
NIA‐AA research framework: toward a biological definition of Alzheimer's disease
CR Jack Jr, DA Bennett, K Blennow… - Alzheimer's & …, 2018 - Wiley Online Library
Abstract In 2011, the National Institute on Aging and Alzheimer's Association created
separate diagnostic recommendations for the preclinical, mild cognitive impairment, and …
separate diagnostic recommendations for the preclinical, mild cognitive impairment, and …
Dementia prevention, intervention, and care
Executive summary Acting now on dementia prevention, intervention, and care will vastly
improve living and dying for individuals with dementia and their families, and in doing so …
improve living and dying for individuals with dementia and their families, and in doing so …
Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity
It is not known exactly where amyloid-β (Aβ) fibrils begin to accumulate in individuals with
Alzheimer's disease (AD). Recently, we showed that abnormal levels of Aβ42 in …
Alzheimer's disease (AD). Recently, we showed that abnormal levels of Aβ42 in …
Imaging techniques in Alzheimer's disease: a review of applications in early diagnosis and longitudinal monitoring
WM van Oostveen, ECM de Lange - International journal of molecular …, 2021 - mdpi.com
Background. Alzheimer's disease (AD) is a progressive neurodegenerative disorder
affecting many individuals worldwide with no effective treatment to date. AD is characterized …
affecting many individuals worldwide with no effective treatment to date. AD is characterized …
The effects of microglia-associated neuroinflammation on Alzheimer's disease
C Wang, S Zong, X Cui, X Wang, S Wu… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's disease (AD) is defined as a severe chronic degenerative neurological disease
in human. The pathogenic mechanism of AD has been convincingly elucidated by the …
in human. The pathogenic mechanism of AD has been convincingly elucidated by the …
Alzheimer's disease
Although the prevalence of dementia continues to increase worldwide, incidence in the
western world might have decreased as a result of better vascular care and improved brain …
western world might have decreased as a result of better vascular care and improved brain …
Preclinical Alzheimer's disease: definition, natural history, and diagnostic criteria
During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD)
considering the disease as a continuum. Thanks to evolving biomarker research and …
considering the disease as a continuum. Thanks to evolving biomarker research and …
[HTML][HTML] Anti-amyloid-β monoclonal antibodies for Alzheimer's disease: pitfalls and promise
CH Van Dyck - Biological psychiatry, 2018 - Elsevier
The majority of putative disease-modifying treatments in development for Alzheimer's
disease are directed against the amyloid-β (Aβ) peptide. Among the anti-Aβ therapeutic …
disease are directed against the amyloid-β (Aβ) peptide. Among the anti-Aβ therapeutic …