Concise review: MSC-derived exosomes for cell-free therapy

DG Phinney, MF Pittenger - Stem cells, 2017 - academic.oup.com
Mesenchymal stem cell transplantation is undergoing extensive evaluation as a cellular
therapy in human clinical trials. Because MSCs are easily isolated and amenable to culture …

Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases

G Li, T Chen, J Dahlman… - Journal of …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) carry diverse bioactive components including nucleic acids,
proteins, lipids and metabolites that play versatile roles in intercellular and interorgan …

Extracellular vesicles in cancer drug resistance: roles, mechanisms, and implications

Q Yang, J Xu, J Gu, H Shi, J Zhang, J Zhang… - Advanced …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are cell‐derived nanosized vesicles that mediate cell‐to‐cell
communication via transporting bioactive molecules and thus are critically involved in …

Recent advances in exosome-based immunotherapy applied to cancer

J **e, Z Zheng, L Tuo, X Deng, H Tang… - Frontiers in …, 2023 - frontiersin.org
Cancer stands as a prominent contributor to global mortality rates, necessitating immediate
attention toward the exploration of its treatment options. Extracellular vesicles have been …

Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential

Z Lin, Y Wu, Y Xu, G Li, Z Li, T Liu - Molecular cancer, 2022 - Springer
Mesenchymal stem cells (MSCs) are multipotent stromal cells that can be obtained from
various human tissues and organs. They can differentiate into a wide range of cell types …

Understanding exosomes: Part 2—Emerging leaders in regenerative medicine

RJ Miron, NE Estrin, A Sculean… - Periodontology 2000, 2024 - Wiley Online Library
Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells
with the ability to communicate with other tissues and cell types over long distances. Their …

Understanding drug sensitivity and tackling resistance in cancer

JW Tyner, F Haderk, A Kumaraswamy… - Cancer …, 2022 - aacrjournals.org
Decades of research into the molecular mechanisms of cancer and the development of
novel therapeutics have yielded a number of remarkable successes. However, our ability to …

Mircrining the injured heart with stem cell-derived exosomes: an emerging strategy of cell-free therapy

KH Haider, B Aramini - Stem cell research & therapy, 2020 - Springer
Bone marrow-derived mesenchymal stem cells (MSCs) have successfully progressed to
phase III clinical trials successive to an intensive in vitro and pre-clinical assessment in …

The role of bone marrow mesenchymal stem cell derived extracellular vesicles (MSC-EVs) in normal and abnormal hematopoiesis and their therapeutic potential

AK Batsali, A Georgopoulou, I Mavroudi… - Journal of clinical …, 2020 - mdpi.com
Mesenchymal stem cells (MSCs) represent a heterogeneous cellular population responsible
for the support, maintenance, and regulation of normal hematopoietic stem cells (HSCs). In …

[HTML][HTML] Role of Acute Myeloid Leukemia (AML)-Derived exosomes in tumor progression and survival

AH Amin, LM Al Sharifi, AJ Kakhharov… - Biomedicine & …, 2022 - Elsevier
Acute myeloid leukemia (AML) is a quickly aggressive hematopoietic disorder that progress
due to the accumulation and clonal expansion of immature myeloid cells. Despite the latest …