Single-cell omics: experimental workflow, data analyses and applications
Cells are the fundamental units of biological systems and exhibit unique development
trajectories and molecular features. Our exploration of how the genomes orchestrate the …
trajectories and molecular features. Our exploration of how the genomes orchestrate the …
WebCSEA: web-based cell-type-specific enrichment analysis of genes
Human complex traits and common diseases show tissue-and cell-type-specificity. Recently,
single-cell RNA sequencing (scRNA-seq) technology has successfully depicted cellular …
single-cell RNA sequencing (scRNA-seq) technology has successfully depicted cellular …
Recruitment of CXCR4+ type 1 innate lymphoid cells distinguishes sarcoidosis from other skin granulomatous diseases
Sarcoidosis is a multiorgan granulomatous disease that lacks diagnostic biomarkers and
targeted treatments. Using blood and skin from patients with sarcoid and non-sarcoid skin …
targeted treatments. Using blood and skin from patients with sarcoid and non-sarcoid skin …
Single-cell multiomics decodes regulatory programs for mouse secondary palate development
Perturbations in gene regulation during palatogenesis can lead to cleft palate, which is
among the most common congenital birth defects. Here, we perform single-cell multiome …
among the most common congenital birth defects. Here, we perform single-cell multiome …
scGWAS: landscape of trait-cell type associations by integrating single-cell transcriptomics-wide and genome-wide association studies
Background The rapid accumulation of single-cell RNA sequencing (scRNA-seq) data
presents unique opportunities to decode the genetically mediated cell-type specificity in …
presents unique opportunities to decode the genetically mediated cell-type specificity in …
CellSTAR: a comprehensive resource for single-cell transcriptomic annotation
Y Zhang, H Sun, W Zhang, T Fu, S Huang… - Nucleic Acids …, 2024 - academic.oup.com
Large-scale studies of single-cell sequencing and biological experiments have successfully
revealed expression patterns that distinguish different cell types in tissues, emphasizing the …
revealed expression patterns that distinguish different cell types in tissues, emphasizing the …
Automatic cell type annotation using marker genes for single-cell RNA sequencing data
Y Chen, S Zhang - Biomolecules, 2022 - mdpi.com
Recent advancement in single-cell RNA sequencing (scRNA-seq) technology is gaining
more and more attention. Cell type annotation plays an essential role in scRNA-seq data …
more and more attention. Cell type annotation plays an essential role in scRNA-seq data …
Identifying candidate genes and drug targets for Alzheimer's disease by an integrative network approach using genetic and brain region-specific proteomic data
Genome-wide association studies (GWAS) have identified more than 75 genetic variants
associated with Alzheimer's disease (ad). However, how these variants function and impact …
associated with Alzheimer's disease (ad). However, how these variants function and impact …
Integrated single‐cell and spatial transcriptomic profiling reveals higher intratumour heterogeneity and epithelial–fibroblast interactions in recurrent bladder cancer
ZD Shi, Z Sun, ZB Zhu, X Liu, JZ Chen… - Clinical and …, 2023 - Wiley Online Library
Background Recurrent bladder cancer is the most common type of urinary tract malignancy;
nevertheless, the mechanistic basis for its recurrence is uncertain. Innovative technologies …
nevertheless, the mechanistic basis for its recurrence is uncertain. Innovative technologies …
Methods for cell-type annotation on scRNA-seq data: A recent overview
The evolution of single-cell technology is ongoing, continually generating massive amounts
of data that reveal many mysteries surrounding intricate diseases. However, their drawbacks …
of data that reveal many mysteries surrounding intricate diseases. However, their drawbacks …