The localization of mRNAs to subcellular compartments provides a mechanism for
regulating gene expression with exquisite temporal and spatial control. Recent studies …

Brain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission
and long-term potentiation (LTP) in the hippocampus and in other brain regions, playing a …

RNA transport is an important and fundamental event for local protein synthesis, especially
in neurons. RNA is transported as large granules, but little is known about them. Here, we …

Long-lasting forms of synaptic plasticity and memory are dependent on new protein
synthesis. Recent advances obtained from genetic, physiological, pharmacological, and …

Many cellular functions require the synthesis of a specific protein or functional cohort of
proteins at a specific time and place in the cell. Local protein synthesis in neuronal dendrites …

RNA localization contributes to cell polarity and synaptic plasticity. Evidence will be
discussed that RNA transport and local translation in neurons may be more intimately linked …

The presence of polyribosomes in dendritic spines suggests a potential involvement of local
protein synthesis in the modification of synapses. Dendritic spine and synapse ultrastructure …

Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …

Abstract Changes in gene expression are required for long-lasting synaptic plasticity and
long-term memory in both invertebrates and vertebrates. Regulation of local protein …

Background: Memory formation after olfactory learning in Drosophila displays behavioral
and molecular properties similar to those of other species. Particularly, long-term memory …