Although dementia has been described in ancient texts over many centuries (eg,“Be kind to
your father, even if his mind fail him.”–Old Testament: Sirach 3: 12), our knowledge of its …

Thanks to its safety and accessibility, magnetic resonance imaging (MRI) is extensively used
in clinical routine and research field, largely contributing to our understanding of the …

It is widely assumed that incipient protein pathology in the medial temporal lobe instigates
the loss of episodic memory in Alzheimer's disease, one of the earliest cognitive deficits in …

Functional and structural connectivity measures, as assessed by means of functional and
diffusion MRI, are emerging as potential intermediate biomarkers for Alzheimer disease (AD) …

Lipid metabolism is fundamental for brain development and function, but its roles in normal
and pathological neural stem cell (NSC) regulation remain largely unexplored. Here, we …

Abstract See Schott and Fox (doi: 10.1093/brain/awv405) for a scientific commentary on this
article. Alzheimer's disease is a multifactorial dementia disorder characterized by early …

Increased hyperphosphorylated tau and the formation of intracellular neurofibrillary tangles
are associated with the loss of neurons and cognitive decline in Alzheimer's disease, and …

Neurovascular dysfunction, including blood–brain barrier (BBB) breakdown and cerebral
blood flow (CBF) dysregulation and reduction, are increasingly recognized to contribute to …

White matter alterations are present in the majority of patients with Alzheimer's disease type
dementia. However, the spatiotemporal pattern of white matter changes preceding dementia …

Alzheimer's disease (AD) is recognized to have a long presymptomatic period, during which
there is progressive accumulation of molecular pathology, followed by inexorable neuronal …