Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies

Q Zhou, Y Meng, D Li, L Yao, J Le, Y Liu… - Signal transduction and …, 2024 - nature.com
Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

Epigenetics-targeted drugs: Current paradigms and future challenges

W Dai, X Qiao, Y Fang, R Guo, P Bai, S Liu… - … and Targeted Therapy, 2024 - nature.com
Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

Metabolism-regulated ferroptosis in cancer progression and therapy

L Ye, X Wen, J Qin, X Zhang, Y Wang, Z Wang… - Cell Death & …, 2024 - nature.com
Cancer metabolism mainly includes carbohydrate, amino acid and lipid metabolism, each of
which can be reprogrammed. These processes interact with each other to adapt to the …

FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer

N Lorito, A Subbiani, A Smiriglia, M Bacci… - EMBO Molecular …, 2024 - embopress.org
Triple-negative breast cancer (TNBC) has limited therapeutic options, is highly metastatic
and characterized by early recurrence. Lipid metabolism is generally deregulated in TNBC …

Hypoxia-Responsive lncRNA AC115619 Encodes a Micropeptide That Suppresses m6A Modifications and Hepatocellular Carcinoma Progression

Q Zhang, T Wei, L Yan, S Zhu, W **, Y Bai… - Cancer …, 2023 - aacrjournals.org
Long noncoding RNAs (lncRNA) regulate a number of aspects of cancer biology. Recent
research has shown that lncRNAs can encode micropeptides that mediate their functions in …

High‐Throughput Host–Microbe Single‐Cell RNA Sequencing Reveals Ferroptosis‐Associated Heterogeneity during Acinetobacter baumannii Infection

H Meng, T Zhang, Z Wang, Y Zhu, Y Yu… - Angewandte Chemie …, 2024 - Wiley Online Library
Interactions between host and bacterial cells are integral to human physiology. The
complexity of host–microbe interactions extends to different cell types, spatial aspects, and …

[HTML][HTML] Investigating autophagy and intricate cellular mechanisms in hepatocellular carcinoma: emphasis on cell death mechanism crosstalk

G Wang, X Jiang, P Torabian, Z Yang - Cancer Letters, 2024 - Elsevier
Hepatocellular carcinoma (HCC) stands as a formidable global health challenge due to its
prevalence, marked by high mortality and morbidity rates. This cancer type exhibits a …

The role of m6A and m6Am RNA modifications in the pathogenesis of diabetes mellitus

D Benak, S Benakova, L Plecita-Hlavata… - Frontiers in …, 2023 - frontiersin.org
The rapidly develo** research field of epitranscriptomics has recently emerged into the
spotlight of researchers due to its vast regulatory effects on gene expression and thereby …

Lenvatinib in hepatocellular carcinoma: resistance mechanisms and strategies for improved efficacy

Y Qin, S Han, Y Yu, D Qi, M Ran, M Yang… - Liver …, 2024 - Wiley Online Library
Hepatocellular carcinoma (HCC), one of the most prevalent and destructive causes of
cancer‐related deaths worldwide, approximately 70% of patients with HCC exhibit …

[HTML][HTML] LACTB suppresses liver cancer progression through regulation of ferroptosis

K Zeng, N Huang, N Liu, X Deng, Y Mu, X Zhang… - Redox Biology, 2024 - Elsevier
Ferroptosis, driven by iron-dependent phospholipid peroxidation, is emerging as an intrinsic
cancer defense mechanism. However, the regulatory networks involved in ferroptosis …